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Toxicity Evaluation by Single and Repeated Administration of Yeast Hydrolysate DNF-10

Preventive Nutrition and Food Science 2021년 26권 1호 p.75 ~ 81
안예진, Kim Sin-Geun, 서형주, 정은영,
소속 상세정보
안예진 ( Ahn Ye-Jin ) - Korea University Graduate School Department of Integrated Biomedical and Life Science
 ( Kim Sin-Geun ) - Korea University Graduate School Department of Integrated Biomedical and Life Science
서형주 ( Suh Hyung-Joo ) - Korea University Graduate School Department of Integrated Biomedical and Life Science
정은영 ( Jung Eun-Young ) - Jeonju University Department of Home Economic Education

Abstract


This study aimed at investigating the acute and subacute oral toxicity of yeast hydrolysate (DNF-10) in Sprague-Dawley rats. To determine the acute toxicity of DNF-10, it was orally administered to rats at a dose of 5,000 mg/ kg. Furthermore, to determine subacute toxicity of DNF-10, it was orally administered to female and male rats at a dose of 1,000 mg/kg for 90 days. In the acute toxicity test, the experimental group did not show changes in body and organ weights compared to the corresponding weights in the control group. When compared to female controls, the DNF-10- treated female rats showed decreased red blood cell counts, haemoglobin, and total bilirubin levels; however, the parameters remained within the normal range. In the subacute toxicity test, DNF-10 administration significantly reduced body weight among male rats, which appears attributable to the anti-obesity effect of the compound. In the experimental groups, significant differences in some haematological parameters were considered as non-toxic because the results were within the normal range. These results suggest that DNF-10 is safe and non-toxic at single doses (5,000 mg/kg) and repeated doses (1,000 mg/kg).

키워드

acute toxicity; Saccharomyces cerevisiae; subacute toxicity; yeast hydrolysate

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