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Myelin oligodendrocyte glycoprotein antibody-associated disorders: clinical spectrum, diagnostic evaluation, and treatment options

Clinical and Experimental Pediatrics 2021년 64권 3호 p.103 ~ 110
이윤진, 남상욱, 고아라, 공주현, 변신연,
소속 상세정보
이윤진 ( Lee Yun-Jin ) - Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
남상욱 ( Nam Sang-Ook ) - Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
고아라 ( Ko A-Ra ) - Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
공주현 ( Kong Ju-Hyun ) - Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
변신연 ( Byun Shin-Yun ) - Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics

Abstract


Inflammatory or immune-mediated demyelinating central nervous system (CNS) syndromes include a broad spectrum of clinical phenotype and different overlapping diseases. Antibodies against myelin oligodendrocyte glycoprotein (MOG-Ab) have been found in some cases of these demyelinating diseases, particularly in children. MOG-Ab is associated with a wider clinical phenotype not limited to neuromyelitis optica spectrum disorder, with most patients presenting with optic neuritis, acute disseminated encephalomyelitis (ADEM) or ADEM-like encephalitis with brain demyelinating lesions, and/or myelitis. Using specific cell-based assays, MOG-Ab is becoming a potential biomarker of inflammatory demyelinating disorders of the CNS. A humoral immune reaction against MOG was recently found in monophasic diseases and recurrent/multiphasic clinical progression, particularly in pediatric patients. This review summarizes the data regarding MOG-Ab as an impending biological marker for discriminating between these diverse demyelinating CNS diseases and discusses recent developments, clinical applications, and findings regarding the immunopathogenesis of MOG-Ab-associated disorders.

키워드

Myelin oligodendrocyte glycoprotein; Demyelinating diseases; Neuromyelitis optica; Optic neuritis; Acute disseminated encephalomyelitis

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