잠시만 기다려 주세요. 로딩중입니다.

Implication of microRNA as a potential biomarker of myocarditis

Clinical and Experimental Pediatrics 2022년 65권 5호 p.230 ~ 238
오진희, 김기범, 석희영,
소속 상세정보
오진희 ( Oh Jin-Hee ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Pediatrics
김기범 ( Kim Gi-Beom ) - Seoul National University College of Medicine Seoul National University Children’s Hospital Department of Pediatrics
석희영 ( Seok Hee-Young ) - Seoul National University Hospital Biomedical Research Institute

Abstract


Myocarditis was previously attributed to an epidemic viral infection. Additional harmful reagents, in addition to viruses, play a role in its etiology. Coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis has recently been described, drawing attention to vaccine-induced myocarditis in children and adolescents. Its pathology is based on a series of complex immune responses, including initial innate immune responses in response to viral entry, adaptive immune responses leading to the development of antigen-specific antibodies, and autoimmune responses to cellular injury caused by cardiomyocyte rupture that releases antigens. Chronic inflammation and fibrosis in the myocardium eventually result in cardiac failure. Recent advancements in molecular biology have remarkably increased our understanding of myocarditis. In particular, microRNAs (miRNAs) are a hot topic in terms of the role of new biomarkers and the pathophysiology of myocarditis. Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590. Despite the lack of clinical trials of miRNA intervention in myocarditis yet, multiple clinical trials of miRNAs in other cardiac diseases have been aggressively conducted to help pave the way for future research, which is bolstered by the success of recently U.S. Food and Drug Administration-approved small-RNA medications. This review presents basic information and recent research that focuses on myocarditis and related miRNAs as a potential novel biomarker and the therapeutics.

키워드

Myocarditis; Heart; MicroRNA; Circulating; Biomarker; RNA medication

원문 및 링크아웃 정보

 

등재저널 정보