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Phytochemical Characteristics of Seeds and Its Effects on the Intestinal Motility and Toxicity of Joannesia princeps

Journal of Medicinal Food 2016년 19권 1호 p.68 ~ 72
Araujo Adriano Cressoni, Guiguer Elen Landgraf, Barbalho Sandra Maria, Bueno Patricia C. S., Lopes Juliana Agostinho, da Silva Bruna Ferreira, Girotto Leticia Cabrini, de Paula Marina Guirro, Zeber Paulo Vitor, de Alvares Goulart Ricardo,
소속 상세정보
 ( Araujo Adriano Cressoni ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Guiguer Elen Landgraf ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Barbalho Sandra Maria ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Bueno Patricia C. S. ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Lopes Juliana Agostinho ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( da Silva Bruna Ferreira ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Girotto Leticia Cabrini ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( de Paula Marina Guirro ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Zeber Paulo Vitor ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( de Alvares Goulart Ricardo ) - University of Marilia University Hospital Department of Gastroenterology

Abstract


Joannesia princeps is a plant commonly used in folk medicine as laxative for menstrual discomfort and as antihelminthic and antimicrobial to reduce edema and improve tissue healing. The seeds are used in many regions of Brazil as laxative; however, studies are needed to confirm its effectiveness and safety. Thus, the aim of this study was to evaluate the effects of using seeds of this plant on intestinal motility of Wistar rats, evaluate the effects and acute toxicity of its management, as well as determine its phytochemical profile. The evaluation of the effect on the intestinal motility was performed according to the model described by Michelin and Salgado (2004) with modifications. For the evaluation of acute toxicity, we used the model described by Craveiro et al. (2008) and Goloni et al. (2005), and for the analysis of the presence of alkaloids, flavonoids, anthraquinones, steroids, and other components, we used the method described by Carvalho et al. (2006). The results showed that J. princeps exhibits laxative effects similar to those of Senna species such as Cassia angustifolia and the phytochemical analysis of ethanol and aqueous extracts showed the presence of alkaloids, triterpenes, and/or steroids compounds. Acute toxicity showed in the first 12?h: piloerection, contortion, decreased respiratory rate, diarrhea, and weight loss. After this period, these changes were no longer observed. It was concluded that the seeds of this plant have potential laxative activity, confirming the popular use and that the dose of 5?g/kg can be considered safe for consumption.

키워드

gastrointestinal motility; Joannesia princeps; toxicity; Wistar rats

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