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Topical Application of Angelica sinensis Improves Pruritus and Skin Inflammation in Mice with Atopic Dermatitis-Like Symptoms

Journal of Medicinal Food 2016년 19권 1호 p.98 ~ 105
이재홍, 최유연, 김미혜, 한재민, 이지은, 김은혜, 홍종기, 김진주, 양웅모,
소속 상세정보
이재홍 ( Lee Jae-Hong ) - Kyung Hee University College of Korean Medicine Department of Convergence Korean Medical Science
최유연 ( Choi You-Yeon ) - Kyung Hee University College of Korean Medicine Department of Convergence Korean Medical Science
김미혜 ( Kim Mi-Hye ) - Kyung Hee University College of Korean Medicine Department of Convergence Korean Medical Science
한재민 ( Han Jae-Min ) - Kyung Hee University College of Korean Medicine Department of Convergence Korean Medical Science
이지은 ( Lee Ji-Eun ) - Kyung Hee University College of Korean Medicine Department of Convergence Korean Medical Science
김은혜 ( Kim Eun-Hye ) - Kyung Hee University College of Pharmacy
홍종기 ( Hong Jong-Ki ) - Kyung Hee University College of Pharmacy
김진주 ( Kim Jin-Ju ) - Kyung Hee University College of Pharmacy Department of Oriental Physiology
양웅모 ( Yang Woong-Mo ) - Kyung Hee University College of Korean Medicine Department of Convergence Korean Medical Science

Abstract


Angelica sinensis (AS) is one of the most popular medicinal foods used as a hematopoietic herb and also traditionally applied topically for skin disorders. However, the effectiveness of AS on atopic dermatitis (AD) has not been reported yet. This study was conducted to evaluate the antipruritic and anti-inflammatory effects of AS on regulating AD-related mediators in DNCB (2,4-dinitrochlorobenzene)-induced mice. AS was topically applied to the dorsal skin of DNCB-challenged mice for 11 days. Alteration of skin thickness was measured for assessment of histological improvement. In addition, the number of mast cells, the level of serum immunoglobulin E (IgE), the counting of scratching behavior, and the expression of substance P were evaluated. Also, the expressions of cytokines, nuclear factor κB (NF-κB), phospho-IκBα, and mitogen-activated protein kinases (MAPKs) were measured for evaluating the improvement of skin inflammation. The repeated treatment of AS significantly inhibited the skin thickness, the number of mast cells, and the level of serum IgE. Moreover, AS significantly suppressed the increased scratching behavior and the expression of substance P compared to the DNCB group. Topical application of AS also reduced the level of cytokines (IL-4, IL-6, TNF-α, and IFN-γ) as well as the expressions of NF-κB, phospho-IκBα, and phospho-MAPKs in the dorsal skin. The results of our study suggest that topical application of AS might have efficacy for modulating pruritus and inflammation in AD. Further studies are required to further characterize the mechanism of actions of AS.

키워드

Angelica sinensis; anti-inflammation; atopic dermatitis; pruritus

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