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Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization

Journal of Medicinal Food 2016년 19권 1호 p.106 ~ 109
Yang Sung-Jae, Jo Hyoung, 김경아, 안홍열, 강석우, 정상훈,
소속 상세정보
 ( Yang Sung-Jae ) - University of Ulsan College of Medicine Gangneung Asan Hospital Department of Ophthalmology
 ( Jo Hyoung ) - Korea Institute of Science and Technology Natural Product Research Center
김경아 ( Kim Kyung-A ) - Korea Institute of Science and Technology Natural Product Research Center
안홍열 ( Ahn Hong-Ryul ) - Korea Institute of Science and Technology Natural Product Research Center
강석우 ( Kang Suk-Woo ) - Korea Institute of Science and Technology Natural Product Research Center
정상훈 ( Jung Sang-Hoon ) - Korea Institute of Science and Technology Natural Product Research Center

Abstract


The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100?mg/kg EEDK group, and 200?mg/kg EEDK group was 43.3%?±?5.5%, 337.7%?±?2.5%, and 27.2%?±?4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.

키워드

alkali burn; angiogenic factors; corneal neovascularization; Diospyros kaki; eye diseases

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