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Protective Effect of Areca catechu Leaf Ethanol Extract Against Ethanol-Induced Gastric Ulcers in ICR Mice

Journal of Medicinal Food 2016년 19권 2호 p.127 ~ 132
이강파, 최난희, Sudjarwo Giftania Wardani, 안상현, 박인식, Lee Sang-Rak, 홍희옥,
소속 상세정보
이강파 ( Lee Kang-Pa ) - Konkuk University School of Medicine Department of Medical Science
최난희 ( Choi Nan-Hee ) - Dongguk University College of Korean Medicine Department of Anatomy
 ( Sudjarwo Giftania Wardani ) - Airlangga University Faculty of Pharmacy Department of Pharmacology and Phytochemistry
안상현 ( Ahn Sang-Hyun ) - Dongguk University College of Korean Medicine Department of Anatomy
박인식 ( Park In-Sik ) - Dongguk University College of Korean Medicine Department of Anatomy
 ( Lee Sang-Rak ) - Konkuk University Department of Animal Biosceince and Technology
홍희옥 ( Hong Hee-Ok ) - Konkuk University School of Medicine Department of Medical Science

Abstract


Gastric ulcer is a common digestive disorder that results in considerable suffering. Hence, this digestive pathology has been the focus of a number of recent studies. Although numerous drugs have been developed to treat gastric ulcers, therapeutic approaches for many of the complications associated with these drugs remain to be identified. For this reason, many natural compounds have been explored as alternatives for these drugs. In this study, we have investigated the effectiveness of Areca catechu leaf ethanol extract (ACE) for treating ethanol-induced gastric ulcers in mice. We performed histological as well as immunohistochemical examinations to explore the therapeutic properties of ACE. We also examined the levels of inflammatory signaling molecules to confirm the anti-inflammatory effects of ACE. The histochemical data demonstrate that ACE can protect the mucosal epithelium as well as the vascular supply in the gastric tract. Furthermore, ACE significantly reduced the expression levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 receptor (IL-6R), inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and nuclear factor-kappa B (NF-κB). Taken together, these data suggest that ACE administration may have the potential as an alternative treatment for gastric ulcer because of its cytoprotective and anti-inflammatory effects and ability to promote the rejuvenation and revascularization of the damaged gastric epithelium.

키워드

Areca catechu; COX2; cytoprotection; gastric ulcer; iNOS; NF-κB; TNF-α

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