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Purslane Extract and Glucose Homeostasis in Adults with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety

Journal of Medicinal Food 2016년 19권 2호 p.133 ~ 140
Wainstein Julio, Landau Zohar, Dayan Yosefa Bar, Jakubowicz Daniela, Grothe Torsten, Perrinjaquet-Moccetti Tania, Boaz Mona,
소속 상세정보
 ( Wainstein Julio ) - E. Wolfson Medical Center Diabetes Unit
 ( Landau Zohar ) - E. Wolfson Medical Center Diabetes Unit
 ( Dayan Yosefa Bar ) - E. Wolfson Medical Center Diabetes Unit
 ( Jakubowicz Daniela ) - E. Wolfson Medical Center Diabetes Unit
 ( Grothe Torsten ) - Frutarom Switzerland Ltd.
 ( Perrinjaquet-Moccetti Tania ) - Frutarom Switzerland Ltd.
 ( Boaz Mona ) - Ariel University School of Health Sciences Department of Nutrition

Abstract


Purslane extract (PE) is derived from Portulaca oleracea L., a medicinal plant used in traditional medicine for its antidiabetic properties. This randomized, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PE in improving glucose control, blood pressure, and lipid profile in adults with type 2 diabetes mellitus (T2DM) treated with a single oral hypoglycemic agent at baseline. Subjects were randomized to treatment with three capsules of PE/day or a matched placebo. Change from baseline to the week 12 end-of-follow-up visit measures of glucose homeostasis, hemodynamics, and lipid profile was compared by treatment assignment. In addition, these measures were evaluated in a subgroup of “responders,” defined as patients whose week 12 HbA1c was lower than baseline values, regardless of treatment assignment. This group was further assessed in subgroups of baseline oral hypoglycemic treatment. A total of 63 participants were treated with either PE (n?=?31, 11 females, mean age 52.4?±?7.9 years) or matched placebo (n?=?32, 11 females, mean age 58.3?±?10.8 years). In the total cohort, systolic blood pressure declined significantly more in the PE group than the placebo group: ?7.5?±?5.0 versus ?0.01?±?0.3?mmHg, P?

키워드

purslane; randomized clinical trial; type 2 diabetes

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