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Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK

Journal of Medicinal Food 2016년 19권 2호 p.148 ~ 154
채희성, 채희성, 김영미, 배진경, Sorchhann Sochivak, Yim Sreymom, Han Ling, 백진협, 최영희, 진영원, 김영미, 배진경, Sorchhann Sochivak, Yim Sreymom, Han Ling, 백진협, 최영희, 진영원,
소속 상세정보
채희성 ( Chae Hee-Sung ) - Dongguk University College of Pharmacy
김영미 ( Kim Young-Mi ) - Dongguk University College of Pharmacy
배진경 ( Bae Jin-Kyung ) - Dongguk University College of Pharmacy
 ( Sorchhann Sochivak ) - Dongguk University College of Pharmacy
 ( Yim Sreymom ) - Dongguk University College of Pharmacy
 ( Han Ling ) - Dongguk University College of Pharmacy
백진협 ( Paik Jin-Hyub ) - Korea Research Institute of Bioscience and Biotechnology International Biological Material Research Center
최영희 ( Choi Young-Hee ) - Dongguk University College of Pharmacy
진영원 ( Chin Young-Won ) - Dongguk University College of Pharmacy
김영미 ( Kim Young-Mi ) - Dongguk University College of Pharmacy
배진경 ( Bae Jin-Kyung ) - Dongguk University College of Pharmacy
 ( Sorchhann Sochivak ) - Dongguk University College of Pharmacy
 ( Yim Sreymom ) - Dongguk University College of Pharmacy
 ( Han Ling ) - Dongguk University College of Pharmacy
백진협 ( Paik Jin-Hyub ) - Korea Research Institute of Bioscience and Biotechnology International Biological Material Research Center
최영희 ( Choi Young-Hee ) - Dongguk University College of Pharmacy
진영원 ( Chin Young-Won ) - Dongguk University College of Pharmacy

Abstract


This study investigated the effects of mangosteen on metabolic syndromes in high-fat (HF) diet-fed mice and the underlying mechanisms related to adipogenesis. Mangosteen-supplemented mice gained significantly less body weight, compared with the HF group. The levels were markedly elevated in HF mice for serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, glucose, triglyceride, total cholesterol, low-density lipoprotein (LDL) cholesterol, and free fatty acid; whereas these levels were significantly lower in the 200?mg/kg of the mangosteen extract-treated group. The mangosteen extract did not modify high-density lipoprotein (HDL)-cholesterol, however, LDL-cholesterol was lower and HDL/LDL ratio was higher (9.4 vs. 3.7 in HF group). Furthermore, 200?mg/kg of mangosteen treatment activated the hepatic AMP-activated protein kinase and Sirtuin 1 in an in vivo system. Thus, the results of this study suggest that mangosteen extract exerts antiobesity effects by regulating energy metabolism and hepatic lipid homeostasis.

키워드

AMP-activated protein kinase; antiobesity; Garcinia mangostana; Sirtuin 1

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