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The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research

Journal of Medicinal Food 2016년 19권 3호 p.228 ~ 237
노유헌, 김도희, 이승아, Yin Xing Fu, 박지애, 이무열, 이원복, 이상형, 김재광, 김성수, 정윤화, 명순철, 김태진, 강일준,
소속 상세정보
노유헌 ( Noh Yoo-Hun ) - Chung-Ang University College of Medicine Department of Anatomy and Cell Biology
김도희 ( Kim Do-Hee ) - Naturesense Inc.
이승아 ( Lee Seung-Ah ) - Chung-Ang University College of Medicine Department of Anatomy and Cell Biology
 ( Yin Xing Fu ) - Famenity Inc.
박지애 ( Park Ji-ae ) - Chung-Ang University College of Medicine Department of Anatomy and Cell Biology
이무열 ( Lee Moo-Yeol ) - Chung-Ang University College of Medicine Department of Physiology
이원복 ( Lee Won-Bok ) - Chung-Ang University College of Medicine Department of Anatomy and Cell Biology
이상형 ( Lee Sang-Hyung ) - Seoul National University College of Medicine SMG-SNU Boramae Medical Center Department of Neurosurgery
김재광 ( Kim Jae-Kwang ) - Catholic University College of Medicine Department of Internal Medicine
김성수 ( Kim Sung-Su ) - Dankook University College of Natural Science Department of Food Science and Nutrition
정윤화 ( Jeong Yoon-Hwa ) - Dankook University College of Natural Science Department of Food Science and Nutrition
명순철 ( Myung Soon-Chul ) - Chung-Ang University College of Medicine Department of Urology
김태진 ( Kim Tae-Jin ) - Sungkyunkwan University School of Medicine Department of Molecular and Cellular Biology
강일준 ( Kang Il-Jun ) - Hallym University Department of Food Science and Nutrition

Abstract


Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.

키워드

colpoxerosis; Kupperman's Index; MS-10; menopause; ovariectomized rat

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