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Coenzyme Q10 Exerts Anti-Inflammatory Activity and Induces Treg in Graft Versus Host Disease

Journal of Medicinal Food 2016년 19권 3호 p.238 ~ 244
이성훈, 박민정, 이성희, 조미라,
소속 상세정보
이성훈 ( Lee Seung-Hoon ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
박민정 ( Park Min-Jung ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
이성희 ( Lee Sung-Hee ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
조미라 ( Cho Mi-La ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center

Abstract


The objective of this study was to determine whether coenzyme Q10 (CoQ10) can reduce the severity of graft versus host disease (GVHD) by inducing regulatory T cells (Tregs). CoQ10 or vehicle was orally administrated once a day for 22 days to mice with GVHD. We measured the alloresponse of the T cells and the GVHD clinical scores. Real-time polymerase chain reaction was used to examine messenger RNA (mRNA) level. Flow cytometry and enzyme-linked immunosorbent assay were used to evaluate protein expression. CoQ10 reduced the T-cell alloresponse and the expression of interferon (IFN)-γ and interleukin (IL)-17. The severity of GVHD and gene expressions of IL-6 and tumor necrosis factor (TNF)-α decreased with CoQ10 treatment. Furthermore, CoQ10 promoted weight gain and survival in GVHD mice. Flow cytometry revealed that CoQ10 dose dependently induced Treg differentiation, but FK506, an immunosuppressive drug, decreased Treg differentiation dose dependently. In conclusion, CoQ10 downregulates the alloreactivity of T cells and reduces GVHD severity, enhancing the differentiation of Tregs.

키워드

coenzyme Q10; graft versus host disease; regulatory T cells

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