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Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity

Journal of Medicinal Food 2016년 19권 3호 p.281 ~ 289
최수정, 오승상, 김초롱, 권윤경, 서수환, 김재겸, 박귀근, 손승렬, 신동훈,
소속 상세정보
최수정 ( Choi Soo-Jung ) - Korea University Functional Food Research Center
오승상 ( Oh Seung-Sang ) - korea university Department of Food and Biotechnology
김초롱 ( Kim Cho-Rong ) - Korea University Functional Food Research Center
권윤경 ( Kwon Yoon-Kyung ) - korea university Department of Food and Biotechnology
서수환 ( Suh Soo-Hwan ) - Ministry of Food and Drug Safety National Institute of Food and Drug Safety Evaluation
김재겸 ( Kim Jae-Kyeom ) - University of Minnesota Department of Food Science and Nutrition
박귀근 ( Park Gwi-Gun ) - Gachon University Department of Food Science and Biotechnology
손승렬 ( Son Seung-Yeol ) - Dankook University Department of Microbiology
신동훈 ( Shin Dong-Hoon ) - korea university Department of Food and Biotechnology

Abstract


One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performed to examine the effects of the P. frutescens extract on trimethyltin chloride-induced impairment of learning and memory in mice. A diet containing P. frutescens extract effectively reversed learning and memory impairment on the Y-maze and passive avoidance tests. To isolate the active compound from the P. frutescens extract, solvent partitioning, silica gel open column chromatography, thin-layer chromatography, and high-performance liquid chromatography were used. The AChE inhibitor was identified as rosmarinic acid.

키워드

Acetylcholinesterase; Alzheimer's disease; Perilla frutescens; Rosmarinic acid; trimethyltin chloride

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