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Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial

Journal of Medicinal Food 2016년 19권 4호 p.346 ~ 352
정한샘, 김소현, 홍순준, 최승철, 최지현, 김종호, 박지연, 조재영, 이태범, 권지웅, 주형준, 박재형, 유철웅, 임도선,
소속 상세정보
정한샘 ( Jeong Han-Saem ) - Korea University Anam Hospital Department of Cardiology
김소현 ( Kim So-Hyeon ) - Korea University Anam Hospital Department of Cardiology
홍순준 ( Hong Soon-Jun ) - Korea University Anam Hospital Department of Cardiology
최승철 ( Choi Seung-Cheol ) - Korea University Anam Hospital Department of Cardiology
최지현 ( Choi Ji-Hyun ) - Korea University Anam Hospital Department of Cardiology
김종호 ( Kim Jong-Ho ) - Korea University Anam Hospital Department of Cardiology
박지연 ( Park Chi-Yeon ) - Korea University Anam Hospital Department of Cardiology
조재영 ( Cho Jae-Young ) - Korea University Anam Hospital Department of Cardiology
이태범 ( Lee Tae-Bum ) - Gochang Black Raspberry Research Institute
권지웅 ( Kwon Ji-Wung ) - Gochang Black Raspberry Research Institute
주형준 ( Joo Hyung-Joon ) - Korea University Anam Hospital Department of Cardiology
박재형 ( Park Jae-Hyoung ) - Korea University Anam Hospital Department of Cardiology
유철웅 ( Yu Cheol-Woong ) - Korea University Anam Hospital Department of Cardiology
임도선 ( Lim Do-Sun ) - Korea University Anam Hospital Department of Cardiology

Abstract


Administration of black raspberry (Rubus occidentalis) is known to improve vascular endothelial function in patients at a high risk for cardiovascular (CV) disease. We investigated short-term effects of black raspberry on circulating endothelial progenitor cells (EPCs) and arterial stiffness in patients with metabolic syndrome. Patients with metabolic syndrome (n?=?51) were prospectively randomized into the black raspberry group (n?=?26, 750?mg/day) and placebo group (n?=?25) during the 12-week follow-up. Central blood pressure, augmentation index, and EPCs, such as CD34/KDR+, CD34/CD117+, and CD34/CD133+, were measured at baseline and at 12-week follow-up. Radial augmentation indexes were significantly decreased in the black raspberry group compared to the placebo group (?5%?±?10% vs. 3%?±?14%, P?

키워드

augmentation index; black raspberry; central blood pressure; endothelial progenitor cells; metabolic syndrome

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