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Myricitrin Ameliorates 6-Hydroxydopamine-Induced Dopaminergic Neuronal Loss in the Substantia Nigra of Mouse Brain

Journal of Medicinal Food 2016년 19권 4호 p.374 ~ 382
김흥덕, Jeong Kyoung-Hoon, 정운주, 김상룡,
소속 상세정보
김흥덕 ( Kim Heung-Deok ) - Kyungpook National University School of Life Sciences
 ( Jeong Kyoung-Hoon ) - Kyungpook National University School of Life Sciences
정운주 ( Jung Un-Ju ) - Kyungpook National University Department of Food Science and Nutrition
김상룡 ( Kim Sang-Ryong ) - Kyungpook National University School of Life Sciences

Abstract


Parkinson's disease (PD) is a chronic and progressive movement disorder, resulting from the degeneration of the nigrostriatal dopaminergic (DA) pathway. The cause of DA neuronal loss in PD is still unclear; however, accumulating evidence suggests that treatment with certain flavonoids can induce neuroprotective properties, such as activation of mammalian target of rapamycin complex 1 (mTORC1) and anti-inflammatory activities in animal models of PD. The bioflavonoid myricitrin is well known for its anti-inflammatory and antioxidant properties. However, it is unclear whether systemic treatment with myricitrin can protect neurons against neurotoxin-induced DA degeneration in vivo via the preservation of tyrosine hydroxylase (TH) activity and the induction of mTORC1 activation. Our results found no significant neuroprotective effect of 30?mg/kg myricitrin on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in the substantia nigra (SN) of mice. However, myricitrin treatment with 60?mg/kg protected DA neurons against 6-OHDA-induced neurotoxicity. Moreover, myricitrin treatment preserved TH enzyme activity and mTORC1 activation in nigral DA neurons in the SN of 6-OHDA-treated mice, and its treatment suppressed an increase in tumor necrosis factor-α expression in activated microglia. These results suggest that myricitrin may have neuroprotective properties linked to mTORC1 activation, preservation of TH enzyme activity, and anti-neuroinflammation for preventing DA neuronal degeneration in vivo.

키워드

dopaminergic neuron; microglia; myricitrin; 6-hydroxydopamine; neuroprotection

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