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Fermented Barley Supplementation Modulates the Expression of Hypothalamic Genes and Reduces Energy Intake and Weight Gain in Rats

Journal of Medicinal Food 2016년 19권 4호 p.418 ~ 426
Pichiah P. B. Tirupathi, 조석호, 한성규, 차연수,
소속 상세정보
 ( Pichiah P. B. Tirupathi ) - Chonbuk National University Department of Food Science and Human Nutrition
조석호 ( Cho Suk-Ho ) - Mealtobalance Co. Ltd.
한성규 ( Han Seong-Kyu ) - Chonbuk National University School of Dentistry Department of Oral Physiology
차연수 ( Cha Youn-Soo ) - Chonbuk National University Department of Food Science and Human Nutrition

Abstract


Dietary fiber and proteins are individually known to decrease feeding, but could result greater weight management benefit when both are combined. We hypothesized that supplementing the diet with fermented barley, being rich in both dietary fiber and proteins, could lower energy intake by modulating the mRNA expression level of hypothalamic genes associated with the regulation of feeding behavior and satiety; thereby decreasing body weight gain. To test our hypothesis, four groups of Sprague Dawley rats were arranged in a 2?×?2 factorial design (n?=?6), low-fat diet with either guar gum (LFD-G) or fermented barley (LFD-FB) and high-fat diet with either guar gum (HFD-G) or fermented barley (HFD-FB). Using oral gavage, fermented barley was given at a dosage of 1500?mg/kg body weight and guar gum was supplemented in an equivalent quantity to that of the fiber in the fermented barley. After 19 weeks, the fermented barley-supplemented groups showed a significant reduction in energy intake, triglyceride, body weight gain, and serum leptin, compared to the guar gum-supplemented groups in both the low- and high-fat diet groups. Likewise, the anorexigenic gene proopiomelanocortin (POMC) and cocaine and amphetamine-regulated transcript (CART) mRNA level were significantly higher in the fermented barley-supplemented groups compared to the guar gum-supplemented groups in rats fed on both high- and low-fat diets. In conclusion, fermented barley supplementation upregulated hypothalamic POMC/CART, decreased energy intake in both low- and high-fat diet groups, and prevented excessive weight gain in rats.

키워드

dietary fiber; proopiomelanocortin; protein; satiety

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