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Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans

Journal of Medicinal Food 2016년 19권 4호 p.427 ~ 433
Sun Quancai, Yue Yiren, Shen Peiyi, Yang Jeremy J., 박연화,
소속 상세정보
 ( Sun Quancai ) - University of Massachusetts Department of Food Science
 ( Yue Yiren ) - University of Massachusetts Department of Food Science
 ( Shen Peiyi ) - University of Massachusetts Department of Food Science
 ( Yang Jeremy J. ) - Amherst Regional High School
박연화 ( Park Yeon-Hwa ) - University of Massachusetts Department of Food Science

Abstract


Cranberry phenolic compounds have been linked to many health benefits. A recent report suggested that cranberry bioactives inhibit adipogenesis in 3T3-L1 adipocytes. Thus, we investigated the effects and mechanisms of the cranberry product (CP) on lipid metabolism using the Caenorhabditis elegans (C. elegans) model. CP (0.016% and 0.08%) dose-dependently reduced overall fat accumulation in C. elegans (N2, wild type) by 43% and 74%, respectively, without affecting its pumping rates or locomotive activities. CP decreased fat accumulation in aak-2 (an ortholog of AMP-activated kinase α) and tub-1 (an ortholog of TUBBY) mutants significantly, but only minimal effects were observed in sbp-1 (an ortholog of sterol response element-binding protein-1) and nhr-49 (an ortholog of peroxisome proliferator-activated receptor-α) mutant strains. We further confirmed that CP downregulated sbp-1, cebp, and hosl-1 (an ortholog of hormone-sensitive lipase homolog) expression, while increasing the expression of nhr-49 in wild-type C. elegans. These results suggest that CP could effectively reduce fat accumulation in C. elegans dependent on sbp-1, cebp, and nhr-49, but not aak-2 and tub-1.

키워드

C. elegans; cranberry; fat accumulation; nhr-49; sbp-1

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