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Bangle (Zingiber purpureum) Improves Spatial Learning, Reduces Deficits in Memory, and Promotes Neurogenesis in the Dentate Gyrus of Senescence-Accelerated Mouse P8

Journal of Medicinal Food 2016년 19권 5호 p.435 ~ 441
Nakai Megumi, Iizuka Michiro, Matsui Nobuaki, Hosogi Kazuko, Imai Akiko, Abe Noriaki, Shiraishi Hisashi, Hirata Ayumu, Yagi Yusuke, Jobu Kohei,
소속 상세정보
 ( Nakai Megumi ) - Kochi Medical Graduate School Department of Pharmacy
 ( Iizuka Michiro ) - Kochi Medical School Hospital Department of Pharmacy
 ( Matsui Nobuaki ) - Tokushima Bunri University Faculty of Pharmaceutical Science
 ( Hosogi Kazuko ) - Kochi Medical Graduate School Department of Pharmacy
 ( Imai Akiko ) - Kochi Medical School Hospital Department of Pharmacy
 ( Abe Noriaki ) - Kochi Medical Graduate School Department of Pharmacy
 ( Shiraishi Hisashi ) - Kochi Medical Graduate School Department of Pharmacy
 ( Hirata Ayumu ) - Kochi Medical Graduate School Department of Pharmacy
 ( Yagi Yusuke ) - Kochi Medical Graduate School Department of Pharmacy
 ( Jobu Kohei ) - Kochi Medical School Hospital Department of Pharmacy

Abstract


Bangle (Zingiber purpureum) is a tropical ginger that is used as a spice in Southeast Asia. Phenylbutenoid dimers isolated from Bangle have exhibited neurotrophic effects in primary cultured rat cortical neurons and PC12 cells. Furthermore, chronic treatment with phenylbutenoid dimers enhances hippocampal neurogenesis in olfactory bulbectomized mice. In this study, we investigated the effects of Bangle extract on behavior and hippocampal neurogenesis in vivo. SAMP8 mice, which are an established model for accelerated aging, with age-related learning and memory impairments, were given a Bangle-containing diet for 1 month, and subsequent behavioral tests and immunohistochemistry for Ki67, a proliferating cell marker, were performed. We found that the Bangle-containing diet improved spatial learning and memory deficits in the Morris water maze and significantly increased the numbers of Ki67-positive cells in the dentate gyrus of the SAMP8 mice. In addition, the Bangle extract exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting in PC12 cells. Our results suggest that Bangle is beneficial for the prevention of age-related progression of cognitive impairment.

키워드

Bangle (Zingiber purpureum); Ki67; neurogenesis; neurotrophic activity; SAMP8; spatial learning and memory

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