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Benefits of Preventive Administration of Chlorella sp. on Visceral Pain and Cystitis Induced by a Single Administration of Cyclophosphamide in Female Wistar Rat

Journal of Medicinal Food 2016년 19권 5호 p.450 ~ 456
Hidalgo-Lucas Sophie, Rozan Pascale, Guerin-Deremaux Laetitia, Baert Blandine, Violle Nicolas, Saniez-Degrave Marie-Helene, Bisson Jean-Francois,
소속 상세정보
 ( Hidalgo-Lucas Sophie ) - Parc Technologique de Nancy-Brabois
 ( Rozan Pascale ) - Parc Technologique de Nancy-Brabois
 ( Guerin-Deremaux Laetitia ) - ROQUETTE
 ( Baert Blandine ) - ROQUETTE
 ( Violle Nicolas ) - Parc Technologique de Nancy-Brabois
 ( Saniez-Degrave Marie-Helene ) - ROQUETTE
 ( Bisson Jean-Francois ) - Parc Technologique de Nancy-Brabois

Abstract


Chlorella sp. is a green microalgae containing nutrients, vitamins, minerals, and chlorophyll. In some communities, Chlorella sp. is a traditional medicinal plant used for the management of inflammation-related diseases. In a rat model, ROQUETTE Chlorella sp. (RCs) benefits were investigated on visceral pain and associated inflammatory parameters related to cystitis both induced by cyclophosphamide (CYP). RCs was orally administered every day from day 1?16 (250 and 500?mg/kg body weight). Six hours after an intraperitoneal injection of 200?mg/kg body weight of CYP, body temperature, general behavior, food intake, and body weight were recorded. Twenty-four hours after CYP injection, rats were tested in two behavioral tests, an open field and the aversive light stimulus avoidance conditioning test, to evaluate the influence of pain on general activity and learning ability of rats. After euthanasia, bladders were weighed, their thickness was scored, and the urinary hemoglobin was measured. RCs orally administered at the two dosages significantly reduced visceral pain and associated inflammatory parameters related to cystitis both induced by CYP injection, and improved rat behavior. To conclude, RCs demonstrated beneficial effects against visceral pain and cystitis.

키워드

behavior; Chlorella sp.; cystitis induced by a chemotherapeutic agent; microalgae; oral administration; pain; rodent

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