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Hibiscus Sabdariffa L. Flowers and Olea Europea L. Leaves Extract-Based Formulation for Hypertension Care: In Vitro Efficacy and Toxicological Profile

Journal of Medicinal Food 2016년 19권 5호 p.504 ~ 512
Micucci Matteo, Angeletti Andrea, Cont Massimiliano, Corazza Ivan, Aldini Rita, Donadio Elisa, Chiarini Alberto, Budriesi Roberta,
소속 상세정보
 ( Micucci Matteo ) - Alma Mater Studiorum-University of Bologna Department of Pharmacy and Biotechnology
 ( Angeletti Andrea ) - Alma Mater Studiorum-University of Bologna Department of Specialistic, Experimental, Diagnostic and Specialty Medicine
 ( Cont Massimiliano ) - National Institute of Biostructure and Biosystems
 ( Corazza Ivan ) - Alma Mater Studiorum-University of Bologna Department of Specialistic, Experimental, Diagnostic and Specialty Medicine
 ( Aldini Rita ) - Alma Mater Studiorum-University of Bologna Department of Pharmacy and Biotechnology
 ( Donadio Elisa ) - Alma Mater Studiorum-University of Bologna Department of Pharmacy and Biotechnology
 ( Chiarini Alberto ) - Alma Mater Studiorum-University of Bologna Department of Pharmacy and Biotechnology
 ( Budriesi Roberta ) - Alma Mater Studiorum-University of Bologna Department of Pharmacy and Biotechnology

Abstract


Olea europaea L. leaves extract (Oe) and Hybiscus sabdariffa L. flowers extract (Hs) have calcium antagonistic properties. Aim of this work was to study the cardiovascular effects of Pres Phytum®, a nutraceutical formulation containing a mixture of the two extracts and the excipients, and investigate its possible off-target effects, using in vitro biological assays on guinea pig isolated organs. Cardiovascular effects were assessed using guinea pig atria and aorta. The effects of Pres Phytum on spontaneous gastrointestinal, urinary, and respiratory tracts smooth muscle contractility were evaluated. Pres Phytum exerted a vasorelaxant effect (IC50?=?2.38?mg/mL) and a negative chronotropic effect (IC50?=?1.04?mg/mL) at concentrations lower than those producing smooth muscle spontaneous contractility alterations in the other organs. Compared to Pres Phytum, the mixture did not exert negative inotropic activity, while it maintained a negative chronotropic efficacy (IC50?=?1.04?mg/mL). These experimental data suggest a possible nutraceutical use of this food supplement for the management of preclinical hypertension.

키워드

hypertension; medicinal plant; herbal drugs; herbal extract; dietary herbal supplement

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