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Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase α Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease

Journal of Medicinal Food 2016년 19권 6호 p.549 ~ 559
홍지혜, 김세라, 김현숙,
소속 상세정보
홍지혜 ( Hong Ji-Hye ) - Sookmyung Women’s University College of Human Ecology Major in Food and Nutrition
김세라 ( Kim Se-Ra ) - Sookmyung Women’s University College of Human Ecology Major in Food and Nutrition
김현숙 ( Kim Hyun-Sook ) - Sookmyung Women’s University College of Human Ecology Major in Food and Nutrition

Abstract


Nonalcoholic fatty liver disease (NAFLD), which is characterized by >5% deposition of triglycerides in hepatocytes, is often referred as a major risk factor for obesity, type 2 diabetes, and hypertension. We investigated the hepatoprotective effect of whole soybean embryos containing bioactive substances such as isoflavones and soyasaponins. For this study, mice were randomly allocated into four groups that were fed different diets for 10 weeks: normal diets and high-fat and high-cholesterol diets (HD), and HD with 10% or 20% soybean embryo powder (10SE-HD and 20SE-HD). Hepatic superoxide dismutase and glutathione peroxidase activity of the experimental groups increased during the period of the study (P?

키워드

adiponectin; AMP-activated protein kinase; antioxidant activity; lipid metabolism; nonalcoholic fatty liver disease; soybean embryo

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