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Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Journal of Medicinal Food 2016년 19권 6호 p.560 ~ 568
Rocha Katya Cristina, dos Santos Vieira Maria Luiza, Beltrame Registila Libania, Cartum Jairo, do N. Alves Sarah Isabel P. M., Azzalis Ligia Ajaime, Junqueira Virginia Berlanga Campos, Pereira Edimar Cristiano, Fonseca Fernando Luiz Affonso,
소속 상세정보
 ( Rocha Katya Cristina ) - Faculty of Medicine of ABC Department of Pathology
 ( dos Santos Vieira Maria Luiza ) - Faculty of Medicine of ABC Department of Pathology
 ( Beltrame Registila Libania ) - Faculty of Medicine of ABC Department of Pathology
 ( Cartum Jairo ) - Faculty of Medicine of ABC Department of Pathology
 ( do N. Alves Sarah Isabel P. M. ) - Federal University of Sao Paulo Institute of Environmental Sciences, Chemistry and Pharmacy
 ( Azzalis Ligia Ajaime ) - Federal University of Sao Paulo Institute of Environmental Sciences, Chemistry and Pharmacy
 ( Junqueira Virginia Berlanga Campos ) - Federal University of Sao Paulo Institute of Environmental Sciences, Chemistry and Pharmacy
 ( Pereira Edimar Cristiano ) - Federal University of Sao Paulo Institute of Environmental Sciences, Chemistry and Pharmacy
 ( Fonseca Fernando Luiz Affonso ) - Faculty of Medicine of ABC Department of Pathology

Abstract


Essential to human health, selenium (Se) has enzymatic functions of fundamental importance to human biology due to its effects on DNA damage repair, its antioxidant properties, and cancer prevention. The best studied relationships between Se and the immune system is its role in the functions of neutrophils and of lymphocytes. Despite these observations, it is not yet clear by which mechanism Se is able to modify the immune status. This was a double-blind, crossover study: Group 1 received Se and Group 2 received placebo (30 days). After this, Group 1 received placebo and Group 2 received Se (30 days). Every 30 days, blood samples were collected for white blood cell count, red blood cell count, and Ig level measurement (IgA, IgG, IgE, IgM). Of the 36 patients, 17 were suffering from leukemia/lymphomas (LL) and 19 from solid tumors (ST). In the ST group's leukogram, a significant increase in neutrophils was observed after Se usage (P?=?.0192). During the analyzed period, Se minimized the triggering of neutropenia cases in both groups. IgA and IgG levels in ST patients were significantly higher than those identified in LL patients after Se usage (P?=?.0051 and P?=?.0055). For IgA, a significant increase in its production, after Se usage, was observed in the ST group when compared to the LL (P?=?.0011). The same did not occur to the IgM and IgE immunoglobulins. In our study, the supplementation with Se reduced the neutropenic cases (LL and ST patients) and reduced IgG and IgA levels in LL and increased in ST group.

키워드

antioxidant activity; cancer; dietary supplementation; glutathione; selenium; ascorbic acid; dietary-induced hyperlipidemia; malondialdehyde

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