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Aqueous Extraction of Citrus unshiu Peel Induces Proangiogenic Effects Through the FAK and ERK1/2 Signaling Pathway in Human Umbilical Vein Endothelial Cells

Journal of Medicinal Food 2016년 19권 6호 p.569 ~ 577
Lee Jung-Whoi, 양동식, 한송이, 윤정훈, 김일웅, 김승준, 김재훈,
소속 상세정보
 ( Lee Jung-Whoi ) - Jeju National University College of Applied Life Sciences Faculty of Biotechnology
양동식 ( Yang Dong-Shik ) - Jeju National University College of Applied Life Sciences Faculty of Biotechnology
한송이 ( Han Song-I ) - Jeju National University College of Applied Life Sciences Faculty of Biotechnology
윤정훈 ( Yun Jeong-Hun ) - Jeju National University College of Applied Life Sciences Faculty of Biotechnology
김일웅 ( Kim Il-Woung ) - Jeju National University College of Applied Life Sciences Faculty of Biotechnology
김승준 ( Kim Seung-Jun ) - Korea Research Institute of Bioscience and Biotechnology
김재훈 ( Kim Jae-Hoon ) - Jeju National University College of Applied Life Sciences Faculty of Biotechnology

Abstract


Citrus unshiu peel has been used empirically as a traditional medicine to improve bronchial asthma and blood circulation in northeast Asian nations, including Korea, Japan, and China. In this study, we report the proangiogenic effects of the aqueous extract of Citrus unshiu peel (AECUP). In human umbilical vein endothelial cells, AECUP significantly induced cellular migration and capillary tube formation. We also demonstrated that AECUP markedly increased the phosphorylation of FAK and ERK1/2 through the integrin signaling pathway. Additionally, we identified that narirutin and hesperidin were major constituents of AECUP and both showed proangiogenic effects, but at different levels. Collectively, these results suggest that the AECUP may have potential as a therapeutic agent for improving angiogenic functions with reduced harmful side effects.

키워드

angiogenesis; Citrus unshiu peel; ERK1/2; FAK; hesperidin

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