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Water-Soluble Components of Sesame Oil Reduce Inflammation and Atherosclerosis

Journal of Medicinal Food 2016년 19권 7호 p.629 ~ 637
Narasimhulu Chandrakala Aluganti, Selvarajan Krithika, Burge Kathryn Young, Litvinov Dmitry, Sengupta Bhaswati, Parthasarathy Sampath,
소속 상세정보
 ( Narasimhulu Chandrakala Aluganti ) - University of Central Florida College of Medicine Burnett School of Biomedical Sciences
 ( Selvarajan Krithika ) - University of Central Florida College of Medicine Burnett School of Biomedical Sciences
 ( Burge Kathryn Young ) - University of Central Florida College of Medicine Burnett School of Biomedical Sciences
 ( Litvinov Dmitry ) - University of Central Florida College of Medicine Burnett School of Biomedical Sciences
 ( Sengupta Bhaswati ) - University of Central Florida College of Medicine Burnett School of Biomedical Sciences
 ( Parthasarathy Sampath ) - University of Central Florida College of Medicine Burnett School of Biomedical Sciences

Abstract


Atherosclerosis, a major form of cardiovascular disease, is now recognized as a chronic inflammatory disease. Nonpharmacological means of treating chronic diseases have gained attention recently. We previously reported that sesame oil aqueous extract (SOAE) has anti-inflammatory properties, both in vitro and in vivo. In this study, we have investigated the antiatherosclerotic properties of SOAE, and the mechanisms, through genes and inflammatory markers, by which SOAE might modulate atherosclerosis. Low-density lipoprotein receptor (LDL-R) knockout female mice were fed with either a high-fat (HF) diet or an HF diet supplemented with SOAE. Plasma lipids and atherosclerotic lesions were quantified after 3 months of feeding. Plasma samples were used for global cytokine array. RNA was extracted from both liver tissue and the aorta, and used for gene analysis. The high-fat diet supplemented with SOAE significantly reduced atherosclerotic lesions, plasma cholesterol, and LDL cholesterol levels in LDL-R?/? mice. Plasma inflammatory cytokines were reduced in the SOAE diet-fed animals, but not significantly, demonstrating potential anti-inflammatory properties of SOAE. Gene analysis showed the HF diet supplemented with SOAE reduced gene expression involved in inflammation and induced genes involved in cholesterol metabolism and reverse cholesterol transport, an anti-inflammatory process. Our studies suggest that a SOAE-enriched diet could be an effective nonpharmacological treatment for atherosclerosis by controlling inflammation and regulating lipid metabolism.

키워드

cholesterol transport; inflammation; lipid metabolism; sesame oil

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