잠시만 기다려 주세요. 로딩중입니다.

Mulberry (Morus alba L.) Fruit Extract Containing Anthocyanins Improves Glycemic Control and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic C57BL/Ksj-db/db Mice

Journal of Medicinal Food 2016년 19권 8호 p.737 ~ 745
최경하, 이현아, 박미화, 한지숙,
소속 상세정보
최경하 ( Choi Kyung-Ha ) - Silla University College of Medical and Life Science Department of Food and Nutrition
이현아 ( Lee Hyun-Ah ) - Pusan National University Department of Food Science and Nutrition
박미화 ( Park Mi-Hwa ) - Silla University College of Medical and Life Science Department of Food and Nutrition
한지숙 ( Han Ji-Sook ) - Pusan National University Department of Food Science and Nutrition

Abstract


The effect of mulberry (Morus alba L.) fruit extract (MFE) on hyperglycemia and insulin sensitivity in an animal model of type 2 diabetes was evaluated. C57BL/Ksj-diabetic db/db mice were divided into three groups: diabetic control, rosiglitazone, and MFE groups. Blood glucose, plasma insulin, and intraperitoneal glucose were measured, and an insulin tolerance test was performed after MFE supplementation in db/db mice. In addition, the protein levels of various targets of insulin signaling were measured by western blotting. The blood levels of glucose and HbA1c were significantly lower in the MFE-supplemented group than in the diabetic control group. Moreover, glucose and insulin tolerance tests showed that MFE treatment increased insulin sensitivity. The homeostatic index of insulin resistance significantly decreased in the MFE-supplemented group relative to the diabetic control group. MFE supplementation significantly stimulated the levels of phosphorylated (p)-AMP-activated protein kinase (pAMPK) and p-Akt substrate of 160?kDa (pAS160) and enhanced the level of plasma membrane-glucose transporter 4 (GLUT4) in skeletal muscles. Further, dietary MFE significantly increased pAMPK and decreased the levels of glucose 6-phosphatase and phosphoenolpyruvate carboxykinase in the liver. MFE may improve hyperglycemia and insulin sensitivity via activation of AMPK and AS160 in skeletal muscles and inhibition of gluconeogenesis in the liver.

키워드

AMPK-AS160-GLUT4 pathway; hyperglycemia; insulin sensitivity; mulberry fruit extract

원문 및 링크아웃 정보

등재저널 정보