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Oral Administration of Collagen Hydrolysates Improves Glucose Tolerance in Normal Mice Through GLP-1-Dependent and GLP-1-Independent Mechanisms

Journal of Medicinal Food 2016년 19권 9호 p.836 ~ 843
Iba Yoshinori, Yoko Koji, Eitoku Itsuka, Goto Masaki, Koizumi Seiko, Sugihara Fumihito, Oyama Hiroshi, Yoshimoto Tadashi,
소속 상세정보
 ( Iba Yoshinori ) - Setsunan University Faculty of Science and Engineering Department of Life Science
 ( Yoko Koji ) - Setsunan University Faculty of Science and Engineering Department of Life Science
 ( Eitoku Itsuka ) - Setsunan University Faculty of Science and Engineering Department of Life Science
 ( Goto Masaki ) - Setsunan University Faculty of Science and Engineering Department of Life Science
 ( Koizumi Seiko ) - Nitta Gelatin Incorporated
 ( Sugihara Fumihito ) - Nitta Gelatin Incorporated
 ( Oyama Hiroshi ) - Setsunan University Faculty of Science and Engineering Department of Life Science
 ( Yoshimoto Tadashi ) - Setsunan University Faculty of Science and Engineering Department of Life Science

Abstract


The aim of this study was to evaluate the antidiabetic properties of collagen hydrolysates (CHs). CHs exhibited dipeptidyl peptidase-IV inhibitory activity and stimulated glucagon-like-peptide-1 (GLP-1) secretion in vitro. We also determined whether CHs improve glucose tolerance in normal mice. Oral administration of CHs suppressed the glycemic response during the oral and intraperitoneal glucose tolerance tests (OGTT and IPGTT), but the effects were weaker in IPGTT than in OGTT. CHs had no effect on the gastric emptying rate. A pretreatment with the GLP-1 receptor antagonist, exendin 9?39 (Ex9), partially reversed the glucose-lowering effects of CHs, but only when coadministered with glucose. CHs administered 45?min before the glucose load potentiated the glucose-stimulated insulin secretion. This potentiating effect on insulin secretion was not reversed by the pretreatment with Ex9, it appeared to be enhanced. These results suggest that CHs improve glucose tolerance by inhibiting intestinal glucose uptake and enhancing insulin secretion, and also demonstrated that GLP-1 was partially involved in the inhibition of glucose uptake, but not essential for the enhancement of insulin secretion.

키워드

blood glucose; collagen peptides; diabetes; dietary supplements; DPP-IV; functional foods; insulin; intestinal glucose uptake

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