잠시만 기다려 주세요. 로딩중입니다.

Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Journal of Medicinal Food 2016년 19권 10호 p.922 ~ 930
Souza Natalia Cabral, de Oliveira Juliana Medeiros, da Silva Morrone Maurilio, Albanus Ricardo D’Oliveira, do Socorro Medeiros Amarante Maria, da Silva Camillo Christina, Langassner Silvana Maria Zucolotto, Gelain Daniel Pens, Moreira Jose Claudio Fonseca, Dalmolin Rodrigo Juliani Siqueira, de Bittencourt Pasquali Matheus Augusto,
소속 상세정보
 ( Souza Natalia Cabral ) - Federal University of Rio Grande do Norte Institute of Tropical Medicine of Rio Grande do Norte
 ( de Oliveira Juliana Medeiros ) - Federal University of Rio Grande do Norte Institute of Tropical Medicine of Rio Grande do Norte
 ( da Silva Morrone Maurilio ) - Federal University of Rio Grande do Sul Department of Biochemistry
 ( Albanus Ricardo D’Oliveira ) - University of Michigan Department of Computational Medicine and Bioinformatics
 ( do Socorro Medeiros Amarante Maria ) - Federal University of Rio Grande do Norte Department of Morphology
 ( da Silva Camillo Christina ) - Federal University of Rio Grande do Norte Department of Morphology
 ( Langassner Silvana Maria Zucolotto ) - Federal University of Rio Grande do Norte Department of Morphology
 ( Gelain Daniel Pens ) - Federal University of Rio Grande do Sul Department of Biochemistry
 ( Moreira Jose Claudio Fonseca ) - Federal University of Rio Grande do Sul Department of Biochemistry
 ( Dalmolin Rodrigo Juliani Siqueira ) - Federal University of Rio Grande do Norte Institute of Tropical Medicine of Rio Grande do Norte
 ( de Bittencourt Pasquali Matheus Augusto ) - Federal University of Rio Grande do Norte Institute of Tropical Medicine of Rio Grande do Norte

Abstract


In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about the medicinal properties of the plants of this genus. In this study, we evaluate the antioxidant and anti-inflammatory of T. subulata leaf extract in an in vitro model of inflammation, using lipopolysaccharide-stimulated RAW-264.7 macrophage cell line. We observed that cotreatment with T. subulata leaf extract was able to reduce the oxidative stress in cells due to inflammatory response. More importantly, we observed that the leaf extract was able to directly modulate inflammatory response by altering activity of members of the mitogen-activated protein kinase pathways. Our results demonstrate for the first time that T. subulata have antioxidant and anti-inflammatory properties, which warrant further investigation of the medicinal potential of this species.

키워드

inflammation; oxidative stress; RAGE; TLR-4; Turnera subulata

원문 및 링크아웃 정보

등재저널 정보