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The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats

Journal of Medicinal Food 2017년 20권 2호 p.189 ~ 196
Djurasevic Sinisa, Jama Adel, Jasnic Nebojsa, Vujovic Predrag, Jovanovic Milos, Mitic-Culafic Dragana, Knezevic-Vukcevic Jelena, Cakic-Milosevic Maja, Ilijevic Konstantin, Djordjevic Jelena,
소속 상세정보
 ( Djurasevic Sinisa ) - University of Belgrade Faculty of Biology
 ( Jama Adel ) - University of Al Jabal Al Gharbi Faculty of Science
 ( Jasnic Nebojsa ) - University of Belgrade Faculty of Biology
 ( Vujovic Predrag ) - University of Belgrade Faculty of Biology
 ( Jovanovic Milos ) - University of Belgrade Faculty of Biology
 ( Mitic-Culafic Dragana ) - University of Belgrade Faculty of Biology
 ( Knezevic-Vukcevic Jelena ) - University of Belgrade Faculty of Biology
 ( Cakic-Milosevic Maja ) - University of Belgrade Faculty of Biology
 ( Ilijevic Konstantin ) - University of Belgrade Faculty of Chemistry
 ( Djordjevic Jelena ) - University of Belgrade Faculty of Biology

Abstract


One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated. The cadmium concentration was measured in the blood, liver, kidney, and feces, as well as the blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as biomarkers of the liver function. Histomorphological changes in the liver and kidney were also determined. Our results revealed that probiotics combined with cadmium increase this metal concentration in feces. As a result, blood, liver, and kidney Cd levels, as well as blood ALT and AST activities were lessened compared to the rat group treated with cadmium only. Besides, probiotics consumed simultaneously with cadmium attenuated histomorphological changes in the liver and kidney caused by cadmium. The rise in lactobacilli number in feces of rats treated simultaneously with cadmium and probiotics results in strong correlation with the increase of Cd concentration in their feces and the decrease of Cd concentration in their blood. We speculate that probiotics actively contribute to cadmium excretion through feces, probably, by its binding to their bacterial cell wall.

키워드

blood; cadmium; feces; liver

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