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Acute Toxicity and Cytotoxicity of Pereskia aculeata, a Highly Nutritious Cactaceae Plant

Journal of Medicinal Food 2017년 20권 4호 p.403 ~ 409
Silva Debora O., Seifert Mauricio, Nora Fabiana R., Bobrowski Vera L., Freitag Rogerio A., Kucera Heidi R., Nora Leonardo, Gaikwad Nilesh W.,
소속 상세정보
 ( Silva Debora O. ) - Federal University of Pelotas Department of Food Science and Technology
 ( Seifert Mauricio ) - Federal University of Pelotas Department of Food Science and Technology
 ( Nora Fabiana R. ) - Federal University of Pelotas Department of Food Science and Technology
 ( Bobrowski Vera L. ) - Federal University of Pelotas Department of Zoology and Genetics
 ( Freitag Rogerio A. ) - Federal University of Pelotas Science Center of Chemistry, Pharmacology and Food
 ( Kucera Heidi R. ) - University of California Davis Department of Nutrition and Environmental Toxicology
 ( Nora Leonardo ) - Federal University of Pelotas Department of Food Science and Technology
 ( Gaikwad Nilesh W. ) - University of California Davis Department of Nutrition and Environmental Toxicology

Abstract


Pereskia aculeata is a Cactaceae plant with valuable nutritional properties, including terrific amounts of protein, minerals, vitamins, and fiber. However, P. aculeata is reported to contain antinutrients and alkaloids in its leaves. In addition, in a study on growth and development, Wistar rats fed with P. aculeata and casein as protein source grew less than the control group (fed with casein only). Therefore, in this study, we evaluated, for the first time, the oral acute toxicity of P. aculeata in rats and also the cytotoxicity behavior of the plant on lettuce seeds. The acute toxicity research was carried out using dried P. aculeata ethanolic extract, in three different doses, administered by gavage to 24 female Wistar rats. The rats were then examined for signs of toxicity, food intake, body weight, and fecal excretion fluctuations, as well as histopathological alterations, using eight different body tissues. The acute toxicity study did not show any difference among the groups in either clinical evaluation or histopathological analyses. For the cytotoxicity study, dried P. aculeata ethanolic extract was applied on lettuce seeds in five different concentrations. These seeds were evaluated for germination, root and shoot length, and mitotic index. The results show that P. aculeata extract affects lettuce root and shoot growth, but not germination or mitotic index. In conclusion, the acute toxicity on rats and the cytogenotoxicity on lettuce of P. aculeata are neglectable, validating the potential of this plant to be used as a functional food.

키워드

cytotoxicity; herbal extract; rats; vegetables

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