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Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes

Journal of Medicinal Food 2017년 20권 5호 p.448 ~ 457
Aslam Farhan, Iqbal Sanaullah, Nasir Muhammad, Anjum Aftab Ahmad, Swan Pamela, Sweazea Karen,
소속 상세정보
 ( Aslam Farhan ) - University of Veterinary and Animal Sciences Lahore Faculty of Biosciences Department of Food Science and Human Nutrition
 ( Iqbal Sanaullah ) - University of Veterinary and Animal Sciences Lahore Faculty of Biosciences Department of Food Science and Human Nutrition
 ( Nasir Muhammad ) - University of Veterinary and Animal Sciences Lahore Faculty of Biosciences Department of Food Science and Human Nutrition
 ( Anjum Aftab Ahmad ) - University of Veterinary and Animal Sciences Lahore Faculty of Veterinary Sciences Department of Microbiology
 ( Swan Pamela ) - Arizona State University School of Nutrition and Health Promotion
 ( Sweazea Karen ) - Arizona State University School of Nutrition and Health Promotion

Abstract


White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO on fasting blood glucose (GLU) and insulin (INS) in male Sprague-Dawley rats with chemically induced diabetes. A secondary aim was to explore other hematological biomarkers of hepatic, cardiac, and renal function. Sixty-three male Sprague-Dawley rats were randomized into standard diet groups, normal control (NCON) (n?=?21) and diabetic control (DCON) (n?=?21), and a diabetic sesame oil (DSO) (n?=?21) group, which were fed a diet containing 12% WSSO. Blood samples were analyzed at 0, 30, and 60 days. Differences between groups and across days were assessed with two-way repeated measures analysis of variance. At baseline, GLU and INS were similar in both diabetic groups, mean 248.4?±?2.8?mg/dL and mean 23.4?±?0.4?μU/mL, respectively. At 60 days, GLU was significantly (P?

키워드

diabetes; insulin; sesame oil; Sprague-Dawley rats; streptozotocin

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