잠시만 기다려 주세요. 로딩중입니다.

Aronia Berry Extract Ameliorates the Severity of Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

Journal of Medicinal Food 2017년 20권 7호 p.667 ~ 675
강사행, 전용덕, 문광현, 이정호, 김대근, 김욱, Myung Hyun, 김종성, 김현주, 방극수, 진종식,
소속 상세정보
강사행 ( Kang Sa-Haeng ) - Woosuk University College of Pharmacy Department of Oriental Pharmacy
전용덕 ( Jeon Yong-Deok ) - Chonbuk National University Department of Oriental Medicine Resources
문광현 ( Moon Kwang-Hyun ) - Sunchang Research Institute of Health and Longevity
이정호 ( Lee Jeong-Ho ) - Sunchang Research Institute of Health and Longevity
김대근 ( Kim Dae-Geun ) - Sunchang Research Institute of Health and Longevity
김욱 ( Kim Wook ) - Sunchang Research Institute of Health and Longevity
 ( Myung Hyun ) - Jeonbuk National University College of Environmental and Bioresource Sciences Department of Ecology Landscape Architecture-Design
김종성 ( Kim Jong-Sung ) - Kunjang University Department of Hotel and Restaurant Culinary Art
김현주 ( Kim Hyun-Ju ) - World Institute of Kimchi
방극수 ( Bang Keuk-Soo ) - Chonbuk National University Department of Oriental Medicine Resources
진종식 ( Jin Jong-Sik ) - Chonbuk National University Department of Oriental Medicine Resources

Abstract


Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a group of inflammatory conditions of the colon and small intestine. UC is a chronic inflammatory disorder of the colon and rectum that includes intervals of acute exacerbation. Although recent studies have suggested that proinflammatory cytokines might have initiated the inflammatory responses in UC, its etiology remains unclear. Aronia berries are rich in dietary polyphenols such as phenolic acids, anthocyanins, flavonoids, and proanthocyanidins with various health benefits, including antioxidant, anti-inflammatory, and antiaging activities. The objective of this study was to determine whether Aronia berry can be an effective intervention for the treatment of UC. BALB/c mice were administered 5% dextran sulfate sodium (DSS) to induce UC. They were then given Aronia berry extracts at concentrations of 10 or 100?mg/kg. During the induction of UC, the expression levels of nuclear factor-kappa B were increased in colonic epithelial cells and immune cells, leading to increased proinflammatory cytokine levels. Aronia berry extract significantly improved the clinical signs of DSS-induced UC, including body weight loss, colon length shortening, and disease activity index increase, with histological markers of colon injury. Furthermore, oral administration of Aronia berry extract inhibited prostaglandin E2 production in DSS-induced colitis and decreased the levels of nitric oxide, interleukin-6, and tumor necrosis factor-α in lipopolysaccharide-stimulated macrophages. These results suggest that Aronia berry extract could efficiently ameliorate clinical signs and inflammatory mediators of UC. Therefore, Aronia berry might be a promising natural treatment for UC.

키워드

Aronia berry; colitis; inflammation; macrophage

원문 및 링크아웃 정보

등재저널 정보