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Mangosteen Extract Prevents Dextran Sulfate Sodium-Induced Colitis in Mice by Suppressing NF-κB Activation and Inflammation

Journal of Medicinal Food 2017년 20권 8호 p.727 ~ 733
채희성, 유병훈, 송지은, Ko Hyuk-Wan, 최영희, 진영원,
소속 상세정보
채희성 ( Chae Hee-Sung ) - Dongguk University College of Pharmacy
유병훈 ( You Byoung-Hoon ) - Dongguk University College of Pharmacy
송지은 ( Song Ji-Eun ) - Dongguk University College of Pharmacy
 ( Ko Hyuk-Wan ) - Dongguk University College of Pharmacy
최영희 ( Choi Young-Hee ) - Dongguk University College of Pharmacy
진영원 ( Chin Young-Won ) - Dongguk University College of Pharmacy

Abstract


In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)?induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120?mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group. MGE downregulated the NF-κB pathway by inhibiting the phosphorylation of IκB and IKK in a dose-dependent manner. These findings suggest that MGE alleviates ulcerative colitis by modulating the NF-κB pathway.

키워드

Garcinia mangostana; inflammatory bowel disease; NF-κB

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