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Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)

Journal of Medicinal Food 2017년 20권 8호 p.790 ~ 796
Kolundzic Marina, Stanojkovic Tatjana, Radovic Jelena, Tacic Ana, Dodevska Margarita, Milenkovic Marina, Sisto Francesca, Masia Carla, Farronato Giampietro, Nikolic Vesna, Kundakovic Tatjana,
소속 상세정보
 ( Kolundzic Marina ) - University of Belgrade Faculty of Pharmacy Department of Pharmacognosy
 ( Stanojkovic Tatjana ) - Institute for Oncology and Radiology of Serbia
 ( Radovic Jelena ) - University of Belgrade Faculty of Pharmacy Department of Pharmacognosy
 ( Tacic Ana ) - University of Nis Faculty of Technology Department of Organic Chemistry
 ( Dodevska Margarita ) - Center for Food Analysis
 ( Milenkovic Marina ) - University of Belgrade Faculty of Pharmacy Department of Microbiology and Immunology
 ( Sisto Francesca ) - University of Milan Department of Biomedical, Surgical and Dental Sciences
 ( Masia Carla ) - University of Milan Department of Biomedical, Surgical and Dental Sciences
 ( Farronato Giampietro ) - University of Milan Department of Biomedical, Surgical and Dental Sciences
 ( Nikolic Vesna ) - University of Nis Faculty of Technology Department of Organic Chemistry
 ( Kundakovic Tatjana ) - University of Belgrade Faculty of Pharmacy Department of Pharmacognosy

Abstract


Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32?μg/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26?±?1.24?134.79?±?0.01?μg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25?mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, β-glucans, and polyphenolic compounds.

키워드

antibacterial activity; ACE inhibitory activity; β-glucan; Cantharellus cibarius; cytotoxicity

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