잠시만 기다려 주세요. 로딩중입니다.

BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence

Journal of Medicinal Food 2017년 20권 9호 p.838 ~ 845
전희영, 박철규, Ham Seok-Won, 최상훈, 이선용, 김정윤, 서선영, Jin Xiong, 김준겸, 은기영, 김은정, 김형기,
소속 상세정보
전희영 ( Jeon Hee-Young ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
박철규 ( Park Cheol-Gyu ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
 ( Ham Seok-Won ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
최상훈 ( Choi Sang-Hun ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
이선용 ( Lee Seon-Yong ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
김정윤 ( Kim Jung-Yun ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
서선영 ( Seo Sun-Young ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
 ( Jin Xiong ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
김준겸 ( Kim Jun-Kyum ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
은기영 ( Eun Ki-Young ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
김은정 ( Kim Eun-Jung ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology
김형기 ( Kim Hyung-Gee ) - Korea University College of Life Sciences and Biotechnology Department of Biotechnology

Abstract


Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and “stemness” both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.

키워드

BRM270; concurrent chemoradiotherapy; glioblastoma multiforme; glioblastoma stem cells; natural plant extract

원문 및 링크아웃 정보

등재저널 정보