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High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats

Journal of Medicinal Food 2017년 20권 9호 p.864 ~ 872
문소희, 이막순, 정선윤, 강보리, 김석영, 박선영, 손혜연, 김종태, 조영희, 김인환, 김영순, 김양하,
소속 상세정보
문소희 ( Moon So-Hee ) - Ewha Womans University Department of Nutritional Science and Food Management
이막순 ( Lee Mak-Soon ) - Ewha Womans University Department of Nutritional Science and Food Management
정선윤 ( Jung Sun-Yoon ) - Ewha Womans University Department of Nutritional Science and Food Management
강보리 ( Kang Bo-Ri ) - Ewha Womans University Department of Nutritional Science and Food Management
김석영 ( Kim Seog-Young ) - Ewha Womans University Department of Nutritional Science and Food Management
박선영 ( Park Seon-Young ) - Ewha Womans University Department of Nutritional Science and Food Management
손혜연 ( Son Hye-Yeon ) - Ewha Womans University Department of Nutritional Science and Food Management
김종태 ( Kim Chong-Tai ) - Korea Food Research Institute
조영희 ( Jo Young-Hee ) - Korea Food Research Institute Research Group of Bioprocess Engineering
김인환 ( Kim In-Hwan ) - Korea University Department of Food and Nutrition
김영순 ( Kim Young-Soon ) - Korea University Department of Food and Nutrition
김양하 ( Kim Yang-Ha ) - Ewha Womans University Department of Nutritional Science and Food Management

Abstract


Stress contributes to physiological changes such as weight loss and hormonal imbalances. The aim of the present study was to investigate antistress effects of high hydrostatic pressure extract of ginger (HPG) in immobilization-stressed rats. Male Sprague-Dawley rats (n?=?24) were divided into three groups as follows: control (C), immobilization stress (2?h daily, for 2 weeks) (S), and immobilization stress (2?h daily, for 2 weeks) plus oral administration of HPG (150?mg/kg body weight/day) (S+G). Immobilization stress reduced the body weight gain and thymus weight by 50.2% and 31.3%, respectively, compared to the control group. The levels of serum aspartate transaminase, alanine transaminase, and corticosterone were significantly higher in the stress group, compared to the control group. Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland. HPG administration also increased the body weight gain and thymus weight by 12.7% and 16.6%, respectively, compared to the stress group. Furthermore, the mRNA levels of Th, Dbh, phenylethanolamine-N-methyltransferase, and P450scc were elevated by the HPG treatment when compared to the stress group. These results suggest that HPG would have antistress effects partially via the reversal of stress-induced physiological changes and suppression of mRNA expression of genes related to corticosterone and catecholamine synthetic enzymes.

키워드

body weight gain; corticosterone; gene expression; thymus weight

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