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Cardioprotective Effects of a Phlorotannin Extract Against Doxorubicin-Induced Cardiotoxicity in a Rat Model

Journal of Medicinal Food 2017년 20권 10호 p.944 ~ 950
안효석, 이동현, 김태정, 신현철, 전희경,
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안효석 ( Ahn Hyo-Suk ) - Catholic University College of Medicine Uijeongbu St. Mary’s Hospital Department of Internal Medicine
이동현 ( Lee Dong-Hyeon ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
김태정 ( Kim Tae-Jung ) - Catholic University College of Medicine Department of Hospital Pathology
신현철 ( Shin Hyeon-Cheol ) - State University of New York CEWIT Center for Systems Biology
전희경 ( Jeon Hui-Kyung ) - Catholic University College of Medicine Uijeongbu St. Mary’s Hospital Department of Internal Medicine

Abstract


Long-term therapy with doxorubicin (DOX) is associated with high incidence of cumulative and irreversible dilated cardiomyopathy. The goal of this study was to evaluate the cardioprotective effects and safety of a phlorotannin extract from a brown algae Ecklonia cava (Seapolynol™, SPN) against DOX-induced cardiotoxicity in a rat model. A total of 42 rats were divided into six groups: control, low-dose SPN (LDS), high-dose SPN (HDS), DOX, DOX with low-dose SPN (DOX+LDS), and DOX with high-dose SPN (DOX+HDS). Echocardiography was performed at baseline and after 6 weeks. In left ventricular (LV) ejection fraction, DOX and DOX+LDS groups showed significant decreases (P?

키워드

doxorubicin-induced cardiomyopathy; echocardiography; Ecklonia cava; electron microscopy; phlorotannin

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