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Fermented Rice Germ Extract Alleviates Morphological and Functional Damage to Murine Gastrocnemius Muscle by Inactivation of AMP-Activated Protein Kinase

Journal of Medicinal Food 2017년 20권 10호 p.969 ~ 980
Tanaka Miyu, Yoshino Yuta, Takeda Shogo, Toda Kazuya, Shimoda Hiroshi, Tsuruma Kazuhiro, Shimazawa Masamitsu, Hara Hideaki,
소속 상세정보
 ( Tanaka Miyu ) - Gifu Pharmaceutical University Department of Biofunctional Evaluation
 ( Yoshino Yuta ) - Gifu Pharmaceutical University Department of Biofunctional Evaluation
 ( Takeda Shogo ) - Oryza Oil and Fat Chemical Co. Ltd.
 ( Toda Kazuya ) - Oryza Oil and Fat Chemical Co. Ltd.
 ( Shimoda Hiroshi ) - Oryza Oil and Fat Chemical Co. Ltd.
 ( Tsuruma Kazuhiro ) - Gifu Pharmaceutical University Department of Biofunctional Evaluation
 ( Shimazawa Masamitsu ) - Gifu Pharmaceutical University Department of Biofunctional Evaluation
 ( Hara Hideaki ) - Gifu Pharmaceutical University Department of Biofunctional Evaluation

Abstract


Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced muscle atrophy. Daily oral FRGE administration increased muscle weight and strength. In addition, myofiber size in gastrocnemius muscle of FRGE-treated mice was increased as revealed by morphological quantification. Activation of AMP-activated protein kinase (AMPK) signaling, which inhibits protein synthesis and stimulates protein degradation in gastrocnemius muscle, was significantly attenuated in the FRGE-treated mice compared with control mice. Expression level of forkhead box 3a (FOXO3a) protein was also significantly decreased in the FRGE-treated group. Moreover, the decrease in mean myofiber cross-sectional area in immobilized hindlimb in vehicle-treated mice was inhibited by FRGE treatment in histological analysis. In conclusion, FRGE increased the strength and weight of gastrocnemius muscle and myofiber size, and reduced immobilization-induced muscle atrophy in mice. These findings indicated that FRGE might be beneficial in preventing motor dysfunction in a range of conditions, including sarcopenia.

키워드

AMP-activated protein kinase; gastrocnemius muscle; muscle atrophy

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