잠시만 기다려 주세요. 로딩중입니다.

Effect of Euterpe oleracea Mart. Seeds Extract on Chronic Ischemic Renal Injury in Renovascular Hypertensive Rats

Journal of Medicinal Food 2017년 20권 10호 p.1002 ~ 1010
da Costa Cristiane Aguiar, Ognibene Dayane Teixeira, Cordeiro Viviane Silva Cristino, de Bem Graziele Freitas, Santos Izabelle Barcellos, Soares Ricardo Andrade, de Melo Cunha Leticia L., Carvalho Lenize C. R. M., de Moura Roberto Soares, Resende Angela Castro,
소속 상세정보
 ( da Costa Cristiane Aguiar ) - Rio de Janeiro State University Department of Pharmacology
 ( Ognibene Dayane Teixeira ) - Rio de Janeiro State University Department of Pharmacology
 ( Cordeiro Viviane Silva Cristino ) - Rio de Janeiro State University Department of Pharmacology
 ( de Bem Graziele Freitas ) - Rio de Janeiro State University Department of Pharmacology
 ( Santos Izabelle Barcellos ) - Rio de Janeiro State University Department of Pharmacology
 ( Soares Ricardo Andrade ) - Rio de Janeiro State University Department of Pharmacology
 ( de Melo Cunha Leticia L. ) - Rio de Janeiro State University Department of Pharmacology
 ( Carvalho Lenize C. R. M. ) - Rio de Janeiro State University Department of Pharmacology
 ( de Moura Roberto Soares ) - Rio de Janeiro State University Department of Pharmacology
 ( Resende Angela Castro ) - Rio de Janeiro State University Department of Pharmacology

Abstract


Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (acai) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of acai (ASE) fruits in two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C and sham groups. Animals received ASE (200?mg/(kg·day) in drinking water) or vehicle for 40 days. We evaluated serum and urinary parameters, renal structural changes, and oxidative status. The increase in systolic blood pressure of the 2K1C group was accompanied by a decrease in left kidney volume and number of glomeruli, as well as an increase in glomerular volume and collagen deposition. ASE prevented the alterations of these parameters, except the reduced kidney volume. Serum levels of urea and creatinine and urinary protein excretion were increased in the 2K1C group and treatment with ASE improved all these functional parameters. The increased oxidative damage in the 2K1C group, assessed by lipid and protein oxidation, was prevented by ASE. The nitrite content and both expression and activity of antioxidant enzymes (superoxide dismutase-1, catalase, and glutathione peroxidase) were lower in the 2K1C group and restored by ASE. ASE substantially reduced renal injury and prevented renal dysfunction in 2K1C rats probably through its antihypertensive and antioxidant effects, providing a natural resource for treatment and prevention of renovascular hypertension-related abnormalities.

키워드

2K1C rats; acai; hypertension; oxidative stress; renal injury

원문 및 링크아웃 정보

등재저널 정보