잠시만 기다려 주세요. 로딩중입니다.

Association Between Coffee Consumption and Circulating Levels of Adiponectin and Leptin

Journal of Medicinal Food 2017년 20권 11호 p.1068 ~ 1075
이창범, 유성훈, 김나연, 김선미, 김성래, 오승준, 지선하, 이정은,
소속 상세정보
이창범 ( Lee Chang-Beom ) - Hanyang University College of Medicine Department of Endocrinology and Metabolism
유성훈 ( Yu Sung-Hoon ) - Hanyang University College of Medicine Department of Endocrinology and Metabolism
김나연 ( Kim Na-Yeon ) - Sookmyung Women’s University Department of Food and Nutrition
김선미 ( Kim Seon-Mee ) - Korea University College of Medicine Department of Family Medicine
김성래 ( Kim Sung-Rae ) - Catholic University College of Medicine Department of Endocrinology and Metabolism
오승준 ( Oh Seung-Joon ) - Kyung Hee University School of Medicine Department of Endocrinology and Metabolism
지선하 ( Jee Sun-Ha ) - Yonsei University Graduate School of Public Health Department of Epidemiology and Health Promotion
이정은 ( Lee Jung-Eun ) - Seoul National University College of Human Ecology Department of Food and Nutrition

Abstract


Coffee has been proposed to have benefits for chronic diseases; however, the relevant mechanism remains to be elucidated. We conducted a cross-sectional study and evaluated the levels of adiponectin and leptin in relation to coffee consumption. We included a total of 4406 individuals (men?=?2587 and women?=?1819) for adiponectin analysis and 2922 individuals (men?=?1731 and women?=?1191) for leptin analysis. Participants answered number of cups of coffee per week and types of coffee they consumed and their serum levels of adiponectin and leptin were measured using an enzyme-linked immunosorbent assay. We found that increasing coffee consumption was associated with increased levels of adiponectin among women; geometric means of adiponectin were 8.0 (95% CI: 7.2?8.9?μg/mL) among women who regularly consumed 15 or greater cups/week, but 7.5 (95% CI: 6.8?8.4?μg/mL) among women who did not consume coffee (P for trend?=?.009). Leptin levels were inversely associated with coffee consumption among both men and women (P for trend?=?.04 for men and 0.04 for women); geometric means of 15 or greater cups of coffee per week were 2.6 (95% CI: 2.4?2.8?ng/mL) among men and 5.1 (95% CI: 4.5?5.8?ng/mL) among women, but for noncoffee drinkers, geometric means were 3.0 (95% CI: 2.7?3.3?ng/mL) for men and 5.8 (95% CI: 5.1?6.6?ng/mL) for women. Coffee consumption was associated with higher circulating levels of adiponectin and lower circulating levels of leptin. Our study may suggest that improvement in adipocyte function contributes to the beneficial metabolic effects of coffee consumption.

키워드

adiponectin; coffee; leptin

원문 및 링크아웃 정보

등재저널 정보