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Dipteryx alata Vogel May Improve Lipid Profile and Atherogenic Indices in Wistar Rats Dipteryx alata and Atherogenic Indices

Journal of Medicinal Food 2017년 20권 11호 p.1121 ~ 1126
Fiorini Adriana Maria Ragassi, Barbalho Sandra Maria, Guiguer Elen Landgraf, Oshiiwa Marie, Mendes Claudemir Gregorio, Vieites Rogerio Lopes, Chies Agnaldo Bruno, de Oliveira Priscilla Bianca, de Souza Maricelma da Silva Soares, Nicolau Claudia Cristina T.,
소속 상세정보
 ( Fiorini Adriana Maria Ragassi ) - Faculty of Food Technology of Marilia Department of Biochemistry and Nutrition
 ( Barbalho Sandra Maria ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Guiguer Elen Landgraf ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Oshiiwa Marie ) - Faculty of Food Technology of Marilia Department of Biochemistry and Nutrition
 ( Mendes Claudemir Gregorio ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Vieites Rogerio Lopes ) - University Estadual Paulista-UNESP Faculty of Agronomic Sciences
 ( Chies Agnaldo Bruno ) - FAMEMA Marilia Faculty of Medicine Department of Pharmacology
 ( de Oliveira Priscilla Bianca ) - FAMEMA Marilia Faculty of Medicine Department of Pharmacology
 ( de Souza Maricelma da Silva Soares ) - University of Marilia School of Medicine Department of Biochemistry and Pharmacology
 ( Nicolau Claudia Cristina T. ) - Faculty of Food Technology of Marilia Department of Biochemistry and Nutrition

Abstract


Worldwide prevalence of noncommunicable chronic degenerative diseases is among the main causes of death worldwide. The consumption of some foods such as nuts and seeds may be beneficial in preventing these diseases. Dipteryx alata Vogel (DA), known popularly as Baru, belongs to the family Fabaceae and is a native fruit tree from the Brazilian savanna. The purpose of this study was to evaluate the use of seeds of DA on the metabolic and oxidative profile of Wistar rats. Animals were divided randomly into four groups (n?=?10): G1 (control group), and G2 (treated with DA 20%), G3 (treated with DA 30%), and G4 (treated with DA 40%). After 40 days, animals were euthanized and metabolic and oxidative profiles were analyzed (glycemia, cholesterol, triglycerides [TGs], high-density lipoprotein-cholesterol [HDL-c], very low-density lipoprotein-cholesterol [VLDL-c], low-density lipoprotein-cholesterol [LDL-c], C reactive protein, aspartate aminotransferase, alanine aminotransferase, Lee index, weight, visceral fat, ferric reducing ability of plasma, and ferric?xylenol orange method. The use of the seeds was effective in reducing TGs, VLDL-c, LDL-c, and increasing HDL-c but did not interfere in the percentage of weight gain, visceral fat, levels of total cholesterol, and oxidative stress. Based on our results, it is possible to say that the use of DA may improve the lipid profile of Wistar rats and we may suggest that the consumption of DA almonds or products prepared with them may be an effective option for the intake of healthy products.

키워드

atherogenic index; Dipteryx alata; lipids; oxidative stress

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