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Long-Term Dietary Supplementation with Yerba Mate Ameliorates Diet-Induced Obesity and Metabolic Disorders in Mice by Regulating Energy Expenditure and Lipid Metabolism

Journal of Medicinal Food 2017년 20권 12호 p.1168 ~ 1175
최명숙, 박효진, 김상룡, 김도연, 정운주,
소속 상세정보
최명숙 ( Choi Myung-Sook ) - Kyungpook National University Department of Food Science and Nutrition
박효진 ( Park Hyo-Jin ) - Kyungpook National University Department of Food Science and Nutrition
김상룡 ( Kim Sang-Ryong ) - Kyungpook National University School of Life Sciences
김도연 ( Kim Do-Yeon ) - Pukyong National University Department of Food Science and Nutrition
정운주 ( Jung Un-Ju ) - Pukyong National University Department of Food Science and Nutrition

Abstract


This study evaluated whether long-term supplementation with dietary yerba mate has beneficial effects on adiposity and its related metabolic dysfunctions in diet-induced obese mice. C57BL/6J mice were randomly divided into two groups and fed their respective experimental diets for 16 weeks as follows: (1) control group fed with high-fat diet (HFD) and (2) mate group fed with HFD plus yerba mate. Dietary yerba mate increased energy expenditure and thermogenic gene mRNA expression in white adipose tissue (WAT) and decreased fatty acid synthase (FAS) mRNA expression in WAT, which may be linked to observed decreases in body weight, WAT weight, epididymal adipocyte size, and plasma leptin level. Yerba mate also decreased levels of plasma lipids (free fatty acids, triglycerides, and total cholesterol) and liver aminotransferase enzymes, as well as the accumulation of hepatic lipid droplets and lipid content by inhibiting the activities of hepatic lipogenic enzymes, such as FAS and phosphatidate phosphohydrolase, and increasing fecal lipid excretion. Moreover, yerba mate decreased the levels of plasma insulin as well as the homeostasis model assessment of insulin resistance, and improved glucose tolerance. Circulating levels of gastric inhibitory polypeptide and resistin were also decreased in the mate group. These findings suggest that long-term supplementation of dietary yerba mate may be beneficial for improving diet-induced adiposity, insulin resistance, dyslipidemia, and hepatic steatosis.

키워드

yerba mate; energy expenditure; obesity; insulin resistance; dyslipidemia; hepatic steatosis

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