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Curcumin Alleviates the Functional Gastrointestinal Disorders of Mice In Vivo

Journal of Medicinal Food 2017년 20권 12호 p.1176 ~ 1183
Yu Jing, Xu Wen-Hua, Sun Wei, Sun Yi, Guo Zhi-Li, Yu Xiao-Ling,
소속 상세정보
 ( Yu Jing ) - Qingdao University Basic Medical College Department of Physiology and Pathophysiology
 ( Xu Wen-Hua ) - Qingdao University Basic Medical College Department of Biochemistry
 ( Sun Wei ) - Qingdao University
 ( Sun Yi ) - Qingdao University
 ( Guo Zhi-Li ) - Qingdao University Weihai Women and Children Hospital
 ( Yu Xiao-Ling ) - Qingdao University Basic Medical College Department of Physiology and Pathophysiology

Abstract


Curcumin is a natural polyphenol extracted from the turmeric rhizome, which has a wide range of biological activities, but until now the effects of curcumin on the gastrointestinal peristalsis have not been fully understood. In vivo study, we observed the effects of curcumin on gastric emptying and intestinal propulsion rates of mice in normal state and in delayed state by atropine (ATR) or nitric oxide precursor L-arginine (L-Arg). An in vitro study explored the direct effects of curcumin on the intestinal contractility, but were studied through measuring spontaneous contraction of isolated jejunum of mice. Our results showed that intragastric administration of curcumin (200?mg/kg/day) for 10?20 days significantly improved gastric emptying and intestinal propulsion rates of mice delayed by ATR. Moreover, intragastric administration of curcumin (200?mg/kg/day) for 15 days also significantly improved mice gastric emptying and intestinal propulsion rates delayed by L-Arg. There was no significant effect on normal gastrointestinal propulsion of mice after intragastric administration of curcumin (200?mg/kg/day) for 1?20 days. When normal isolated jejunum of mice were incubated with curcumin in vitro, the amplitude of the spontaneous contractile waves of jejunum was reduced in a concentration-dependent manner. Moreover, curcumin reduced the amplitude of the contractile waves of jejunum in both contracted and relaxed state induced by acetylcholine or ATR individually. Taken together, our results suggest that curcumin has quite different effects on gastrointestinal peristalsis in vivo and in vitro. Moderate dose of curcumin by intragastric administration for more than 10 days can alleviate the functional gastrointestinal disorders of mice, but cannot affect normal gastrointestinal propulsion.

키워드

curcumin; functional gastrointestinal disorders; gastric emptying; intestinal propulsion; intragastric administration

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