잠시만 기다려 주세요. 로딩중입니다.

A Combination with Probiotic Complex, Zinc, and Coenzyme Q10 Attenuates Autoimmune Arthritis by Regulation of Th17/Treg Balance

Journal of Medicinal Food 2018년 21권 1호 p.39 ~ 46
이선영, 이성훈, 전주연, 서현범, 정경아, 양철우, 박성환, 조미라,
소속 상세정보
이선영 ( Lee Seon-Young ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
이성훈 ( Lee Seung-Hoon ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
전주연 ( Jhun Joo-Yeon ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
서현범 ( Seo Hyeon-Beom ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
정경아 ( Jung Kyung-Ah ) - Impact Biotech
양철우 ( Yang Chul-Woo ) - Catholic University College of Medicine Department of Internal Medicine
박성환 ( Park Sung-Hwan ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center
조미라 ( Cho Mi-La ) - Catholic University Catholic Research Institute of Medical Science The Rheumatism Research Center

Abstract


Probiotic complex, zinc, and coenzyme Q10 (CoQ10) are recognized dietary supplements with an anti-inflammatory role. Although these supplementations are individually known to benefit rheumatoid arthritis (RA), there is no evidence suggesting any synergic effect. The primary goal of this study is to determine whether probiotic complex, zinc, and CoQ10 attenuate the development of collagen-induced arthritis (CIA). The combination of probiotic complex, zinc, and CoQ10 reduced CIA severity by downregulating the levels of IgG, IgG1, and IgG2a in serum. Joint inflammation, bone destruction, and cartilage damage were also improved by the complex. There was a decrease in the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-17, and vascular endothelial growth factor (VEGF) in the joint synovium. The balance between helper T 17 (Th17) cells and regulatory T (Treg) cells was shown to be controlled reciprocally by the complex. These findings suggest that the combination of probiotic complex, zinc, and CoQ10 can ameliorate the development of CIA by inhibiting the expression of proinflammatory cytokines, and is thus an important therapeutic candidate for RA treatment.

키워드

coenzyme Q10; probiotic complex; rheumatoid arthritis; Th17; zinc

원문 및 링크아웃 정보

등재저널 정보