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A Blend of Extracts from Houttuynia cordata, Nelumbo nucifera, and Camellia sinensis Protects Against Ethanol-Induced Liver Damage in C57BL/6 Mice

Journal of Medicinal Food 2018년 21권 2호 p.203 ~ 206
유양희, 이현미, 유호건, 박정진, 김옥경, 김경미, 이민재, 이유현, 이정민, 전우진,
소속 상세정보
유양희 ( You Yang-hee ) - Chonnam National University Division of Food and Nutrition
이현미 ( Lee Hyun-Mi ) - Chonnam National University Division of Food and Nutrition
유호건 ( Yoon Ho-Geun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
박정진 ( Park Jeong-Jin ) - Chonnam National University Division of Food and Nutrition
김옥경 ( Kim Ok-Kyung ) - Chonnam National University Division of Food and Nutrition
김경미 ( Kim Kyung-mi ) - Korea Bio Polytechnic Department of Biofood Analysis
이민재 ( Lee Min-Jae ) - Nutriplan Co. Ltd.
이유현 ( Lee Yoo-Hyun ) - University of Suwon Department of Food and Nutrition
이정민 ( Lee Jeong-min ) - Kyung Hee University Research Institute of Medical Nutrition
전우진 ( Jun Woo-Jin ) - Chonnam National University Division of Food and Nutrition

Abstract


The protective activity of a mixture of aqueous and ethanolic extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. leaves, and Camellia sinensis seed (HNC) was evaluated in C57BL/6 mice. Pretreatment with HNC prevented the elevation of serum aspartate aminotransferase and alanine aminotransferase caused by ethanol-induced hepatic damage. The HNC-treated mice showed significantly lower triglyceride levels, reduced CYP2E1 activity, and increased antioxidant enzyme activities and lipogenic mRNA levels. These results suggest that HNC might be a candidate agent for liver protection against ethanol-induced oxidative damage, through enhancement of antioxidant and antilipogenic activity.

키워드

Camellia sinensis; ethanol; Houttuynia cordata Thunb; liver damage; Nelumbo nucifera G.

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