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Lipolysis-Stimulating Peptide from Soybean Protects Against High Fat Diet-Induced Apoptosis in Skeletal Muscles

Journal of Medicinal Food 2018년 21권 3호 p.225 ~ 232
Asokan Shibu Marthandam, Hung Tsu-Han, Chiang Wen-Dee, Lin Wan-Teng,
소속 상세정보
 ( Asokan Shibu Marthandam ) - Ton Duc Thang University Department for Management of Science and Technology Development
 ( Hung Tsu-Han ) - Tunghai University College of Agriculture Department of Hospitality Management
 ( Chiang Wen-Dee ) - Tunghai University College of Agriculture Department of Food Science
 ( Lin Wan-Teng ) - Tunghai University College of Agriculture Department of Hospitality Management

Abstract


Obesity is generally associated with low-grade chronic inflammation that involves the recruitment of macrophages and other inflammation factors to the adipocytes of obese individuals. Tumor necrosis factor-alpha (TNF-α), a cytokine associated with systemic inflammation, is elevated in conditions of obesity. TNF-α is an important factor that plays an important role in skeletal muscle wasting. Apoptosis of myonuclei contributes to the loss of muscle mass and therefore plays an important role in skeletal muscle atrophy. In mouse models that were fed a high fat diet (HFD), a lipolysis-stimulating peptide-VHVV (purified from hydrolysate resulting from flavourzyme treatment of soy protein) was found to reduce HFD-related apoptotic effects in mice skeletal muscle and potentially control atrophy. HFD fed mice had heavier body weight than those fed with normal chow, and VHVV administration restricted lipid accumulation in muscle tissues of mice fed with HFD but increased nutrient uptake. Moreover, specific concentrations of VHVV regulated TNF-α expression that was elevated by HFD, suppressed apoptosis-related proteins and regulated the proteins of lipid metabolism.

키워드

apoptosis; high fat diet; lipolysis-stimulating peptides; NAFLD; obesity

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