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The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro

Journal of Medicinal Food 2018년 21권 3호 p.244 ~ 253
전용덕, 강사행, 문광현, 이정호, 김대근, 김욱, 김종성, 안병용, 진종식,
소속 상세정보
전용덕 ( Jeon Yong-Deok ) - Chonbuk National University Department of Oriental Medicine Resources
강사행 ( Kang Sa-Haeng ) - Chonbuk National University Department of Oriental Medicine Resources
문광현 ( Moon Kwang-Hyun ) - Sunchang Research Institute of Health and Longevity
이정호 ( Lee Jeong-Ho ) - Sunchang Research Institute of Health and Longevity
김대근 ( Kim Dae-Geun ) - Sunchang Research Institute of Health and Longevity
김욱 ( Kim Wook ) - Sunchang Research Institute of Health and Longevity
김종성 ( Kim Jong-Sung ) - Kunjang University Department of Hotel and Restaurant Culinary Art
안병용 ( Ahn Byung-Yong ) - Chonbuk National University Department of Oriental Medicine Resources
진종식 ( Jin Jong-Sik ) - Chonbuk National University Department of Oriental Medicine Resources

Abstract


The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe. Aronia contains a variety of ingredients such as polyphenols, anthocyanins, flavonoids, and tannins. Especially, anthocyanin content in aronia berry is known to be much higher than in other plants and berries. It is known for exerting antioxidant, anti-inflammation, and anti-aging effects. Therefore, this study was conducted to investigate the effects of aronia berry extract intake in multiple low-dose streptozotocin (STZ)-induced T1D and to confirm the functional properties of aronia berry. ICR mice (6-week male) were divided into four groups: control (normal control group), STZ (100?mg/kg of STZ-induced T1D group), AR 10 (STZ with oral administration of aronia 10?mg/kg), and AR 100 (STZ with oral administration of aronia 100?mg/kg). Afterward, STZ was injected in a single dose to induce T1D, and the extract was orally administered daily. Dietary intake and body weight were measured twice a week. We confirmed that aronia berry has the effect of decreasing the increase of blood glucose level and also has the protection effect of pancreas β cell (RINm5F cell). This study confirms the anti-diabetic activity of aronia berry, and it can be expected to increase the utilization according to the results.

키워드

aronia berry; diabetes; RINm5F; streptozotocin

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