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Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats

Journal of Medicinal Food 2018년 21권 4호 p.348 ~ 355
Cai Bingna, Wan Peng, Sun Huili, Chen Deke, Chen Hua, Chen Xin, Pan Jianyu,
소속 상세정보
 ( Cai Bingna ) - Chinese Academy of Sciences South China Sea Institute of Oceanology
 ( Wan Peng ) - Chinese Academy of Sciences South China Sea Institute of Oceanology
 ( Sun Huili ) - Chinese Academy of Sciences South China Sea Institute of Oceanology
 ( Chen Deke ) - Chinese Academy of Sciences South China Sea Institute of Oceanology
 ( Chen Hua ) - Chinese Academy of Sciences South China Sea Institute of Oceanology
 ( Chen Xin ) - Foshan University School of Environment and Chemical Engineering
 ( Pan Jianyu ) - Chinese Academy of Sciences South China Sea Institute of Oceanology

Abstract


Chemotherapeutics, including 5-fluorouracil (5-FU), often damage the intestinal mucosal barrier and cause intestinal mucositis (IM). Supplementation with immunoregulatory polysaccharides from Crassostrea hongkongensis has been shown to positively influence the effectiveness and toxicity of 5-FU. Therefore, we studied the effects of oyster polysaccharides on 5-FU-induced intestinal mucosal damage in rats. The C30?60% ethanol-precipitated fraction of polysaccharides promoted IEC-6 cell proliferation and exhibited a maximal effect at a 0.0195?mg/mL concentration. Moreover, treatment with C30?60% polysaccharide-based nutrition formula (OPNF) partially prevented the 5-FU-induced degenerative changes in the histology and ultrastructure of small intestinal mucosa. In addition, the endotoxin level of rats fed with 5-FU and OPNF decreased to the normal control level. Furthermore, the 5-FU-induced increase of proinflammatory cytokine interleukin (IL)-2 and the decrease of anti-inflammatory cytokine IL-10 level in the peripheral blood were significantly attenuated by OPNF administration. In conclusion, Oyster C30?60% polysaccharides can ameliorate 5-FU-induced IM by partially preventing mucosal damage, reducing inflammation, and promoting immunity.

키워드

Crassostrea hongkongensis; cytokine; enteral nutrition; intestinal mucosa; polysaccharide

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