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The Combination of Probiotic Complex, Rosavin, and Zinc Improves Pain and Cartilage Destruction in an Osteoarthritis Rat Model

Journal of Medicinal Food 2018년 21권 4호 p.364 ~ 371
Kwon Ji-Ye, 이성훈, 전주연, 최정원, 정경아, Cho Keun-Hyung, 김석중, 양철우,
소속 상세정보
 ( Kwon Ji-Ye ) - Catholic University College of Medicine Catholic Research Institute of Medical Science Rheumatism Research Center
이성훈 ( Lee Seung-Hoon ) - Catholic University College of Medicine Catholic Research Institute of Medical Science Rheumatism Research Center
전주연 ( Jhun Joo-Yeon ) - Catholic University College of Medicine Catholic Research Institute of Medical Science Rheumatism Research Center
최정원 ( Choi Jeong-Won ) - Catholic University College of Medicine Catholic Research Institute of Medical Science Rheumatism Research Center
정경아 ( Jung Kyung-Ah ) - Impact Biotech
 ( Cho Keun-Hyung ) - Catholic University College of Medicine Catholic Research Institute of Medical Science Rheumatism Research Center
김석중 ( Kim Seok-Jung ) - Catholic University College of Medicine Uijeongbu St. Mary’s Hospital Department of Orthopedic Surgery
양철우 ( Yang Chul-Woo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine

Abstract


Osteoarthritis (OA), a degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Probiotic complex, rosavin, and zinc have been used as dietary supplements that exhibit anti-inflammatory and antioxidant properties. However, there is no evidence demonstrating a synergic effect in OA. This study aims to determine whether combination with probiotic complex, rosavin, and zinc decreases progression of monosodium iodoacetate (MIA)-induced OA rat model. The combination improved pain levels by preventing cartilage damage. The expression of proinflammatory cytokines and catabolic factors was reduced by the combination within the joint tissue. However, the combination increased anti-inflammatory cytokines as well as the anabolic factor production. The gene level of catabolic factors was decreased with treatment of the combination in chondrocytes isolated from OA patients. These results suggest that the combination can improve MIA development through the inhibition of proinflammatory cytokines and cartilage destruction, thus playing a key role as a therapeutic candidate for OA treatment.

키워드

cartilage; osteoarthritis; probiotic complex; rosavin; zinc

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