잠시만 기다려 주세요. 로딩중입니다.

Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men

Journal of Medicinal Food 2018년 21권 5호 p.445 ~ 453
김종경, 김경애, 최현민, 박승국, Stebbins Charles L.,
소속 상세정보
김종경 ( Kim Jong-Kyung ) - Kyung Hee University Graduate School of Physical Education
김경애 ( Kim Kyung-Ae ) - Kyung Hee University Graduate School of Physical Education
최현민 ( Choi Hyun-Min ) - Kyung Hee University Graduate School of Physical Education
박승국 ( Park Seung-Kook ) - Kyung Hee University College of Life Sciences
 ( Stebbins Charles L. ) - University of California at Davis Department of Internal Medicine

Abstract


We tested the hypothesis that exaggerated pressor responses observed in prehypertensive males (N?=?9) during dynamic exercise are attenuated following acute dietary supplementation with grape seed extract (GSE) (i.e., a single dose). Effects of placebo and GSE (300?mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), total vascular conductance (TVC), and rate?×?pressure product (RPP) in response to two submaximal cycling workloads (40% and 60% VO2peak) were compared 2?h after ingestion of GSE or placebo on different days, 1 week apart. Endothelial function was also evaluated using flow-mediated dilation (FMD). Placebo treatment had no effect on any of the variables. GSE supplementation attenuated MAP at both workloads (40% VO2peak: 115?±?1 vs. 112?±?2?mmHg; 60% VO2peak: 126?±?2 vs. 123?±?2?mmHg) and RPP at the lower workload. Conversely, SV, CO, and TVC were augmented during both workloads. FMD was augmented by GSE (18.9?±?2.0 vs. 12.4%?±?2.0%). These findings indicate that in exercising prehypertensive males, a single dose of GSE reduces blood pressure, peripheral vasoconstriction, and work of the heart and enhances O2 delivery; effects that may be due, in part, to endothelium-dependent vasodilation. We propose that acute GSE treatment represents an intervention that may minimize potential increases in the risk of cardiovascular events during dynamic exercise in prehypertensives.

키워드

blood pressure; dynamic exercise; grape seed extract; prehypertensive men; stroke volume

원문 및 링크아웃 정보

등재저널 정보