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Antiulcerative and Antinociceptive Activities of Casein and Whey Proteins

Journal of Medicinal Food 2018년 21권 6호 p.605 ~ 611
Carrillo Wilman, Monteiro Karin Maia, Spindola Humberto, Ramos Mercedes, de Carvalho Joao Ernesto,
소속 상세정보
 ( Carrillo Wilman ) - Autonomous University of Madrid Research Institute of Food Science
 ( Monteiro Karin Maia ) - State University of Campinas
 ( Spindola Humberto ) - State University of Campinas
 ( Ramos Mercedes ) - Autonomous University of Madrid Research Institute of Food Science
 ( de Carvalho Joao Ernesto ) - State University of Campinas

Abstract


The aim of this study was to evaluate the antiulcerative and antinociceptive activities of milk proteins using the induced gastric ulcer with ethanol rat model and the acetic acid-induced writhing mouse model. Casein (CN), (100, 300, and 1000?mg kg?1) doses presented antiulcerative activity on a dose-dependent manner with values of 30.8%, 41.4%, and 57.0% of inhibition measured using the ulcerative lesions index (ULI), respectively. Whey protein concentrate (WPC), (100, 300, and 1000?mg kg?1) doses presented antiulcerative activity on a dose-dependent manner with values of 48.9%, 65.5%, and 68.22% of ULI inhibition, respectively. CN, casein hydrolysates (CNH), WPC, and whey protein hydrolysates (WPH), (3, 10, and 30?mg kg?1) doses presented antinociceptive activity using the acetic acid-induced writhing in the mouse model. CN (30?mg kg?1) presented a value of 40% of inhibition writhing, and CNH (30?mg kg?1) presented antinociceptive activity with a value up to 46% of writhing inhibition. WPC (30?mg kg?1) presented a value of 52.50%, and WPH (30?mg kg?1) presented antinociceptive activity with a value up to 88.00% of writhing inhibition. In conclusion, CN and WPC demonstrated in vivo antiulcerative properties and represent a promising alternative to be used as protectors of the gastric mucosa. CNH and WPH demonstrated in vivo antiulcerative properties and represent a promising alternative to be used as natural analgesic.

키워드

abdominal writhing; bovine milk; hydrolysates; milk proteins; proteins; ulcers

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