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Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

Journal of Medicinal Food 2018년 21권 7호 p.701 ~ 708
Nakamura Toshio, Yamamura Haruo, 박경호, Pereira Caroline, Uchida Yoshikazu, Horie Noriko, 김무조, Itami Satoshi,
소속 상세정보
 ( Nakamura Toshio ) - Pharma Foods International Co. Ltd.
 ( Yamamura Haruo ) - Charle Co. Ltd.
박경호 ( Park Kyung-Ho ) - Hallym University Department of Food Science and Nutrition
 ( Pereira Caroline ) - Pharma Foods International Co. Ltd.
 ( Uchida Yoshikazu ) - Pharma Foods International Co. Ltd.
 ( Horie Noriko ) - Pharma Foods International Co. Ltd.
김무조 ( Kim Mu-Jo ) - Pharma Foods International Co. Ltd.
 ( Itami Satoshi ) - Osaka University Graduate School of Medicine Department of Regenerative Dermatology

Abstract


Alopecia is divided into two categories: androgenic alopecia and nonandrogenic alopecia. An androgen-dependent abnormality of biological functions causes alopecia in males, but the role of androgens is not yet elucidated in female pattern hair loss (FPHL). Modulation of androgenic activity is not effective in certain kinds of androgenic alopecia in females, as well as in cases of nonandrogenic alopecia in males and females. The hair growth drug, minoxidil, stimulates vascular endothelial growth factor (VEGF) production as well as vascularization and hair growth in females. Yet, because minoxidil has side effects with long-term use, a safe alternative hair growth agent is needed. Whereas hair develops after birth in mammalian species, hair mostly grows in a precocial bird, in the chicken, between hatching days 14 and 15. Therefore, we hypothesized that the chicken egg contains a key hair growth factor. In this study, we demonstrated that water-soluble peptides derived from the egg yolk stimulate VEGF production and human hair follicle dermal papilla cell growth. We also found that these peptides enhance murine hair growth and improve hair growth in FPHL. Finally, we characterized that water-soluble egg yolk peptides induce VEGF expression through insulin growth factor-1 receptor activation-induced hypoxia-inducible factor-1α transcription pathway. We have given the name “hair growth peptide (HGP)” to this water-soluble egg yolk peptide.

키워드

alopecia; chicken egg; female pattern hair loss; IGF-1 receptor; VEGF

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